Literature DB >> 8135744

Calcium promotes membrane association of reticulocyte 15-lipoxygenase.

A Watson1, F J Doherty.   

Abstract

The reticulocyte 15-lipoxygenase (linoleate:oxygen oxidoreductase, EC 1.13.11.12) is implicated in oxidative damage to reticulocyte mitochondria before their elimination by degradation during maturation to the erythrocyte. A proportion of the 15-lipoxygenase sediments with the mitochondrial-rich stromal fraction of density-gradient-fractionated rabbit reticulocytes suggesting a physical association with mitochondria before their elimination. Ca2+ promotes binding of reticulocyte 15-lipoxygenase to isolated rat liver and reticulocyte mitochondria and 15-lipoxygenase-mediated lipid peroxidation of mitochondrial lipids and free linoleic acid. Association of reticulocyte 15-lipoxygenase with isolated mitochondria is not simply a consequence of Ca(2+)-induced swelling, but implies that Ca2+ mediates translocation of soluble lipoxygenase to mitochondrial membranes. Therefore, Ca2+ may have an important physiological role in the regulation of 15-lipoxygenase-mediated targeting of reticulocyte mitochondria for degradation.

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Year:  1994        PMID： 8135744      PMCID： PMC1137950          DOI： 10.1042/bj2980377

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  18 in total

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Journal:  FEBS Lett       Date:  1975-12-01       Impact factor: 4.124

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Journal:  Eur J Biochem       Date:  1979-06-01

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Journal:  Eur J Biochem       Date:  1979-06-01

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Journal:  J Biol Chem       Date:  1990-10-25       Impact factor: 5.157

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Journal:  FEBS Lett       Date:  1986-03-17       Impact factor: 4.124

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Journal:  FEBS Lett       Date:  1985-04-22       Impact factor: 4.124

7.  Use of digitonin extraction to distinguish between autophagic-lysosomal sequestration and mitochondrial uptake of [14C]sucrose in hepatocytes.

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Journal:  Biochem J       Date:  1985-12-15       Impact factor: 3.857

8.  Characterization and separation of the arachidonic acid 5-lipoxygenase and linoleic acid omega-6 lipoxygenase (arachidonic acid 15-lipoxygenase) of human polymorphonuclear leukocytes.

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Journal:  J Biol Chem       Date:  1985-04-10       Impact factor: 5.157

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10.  Identification and isolation of a membrane protein necessary for leukotriene production.

Authors:  D K Miller; J W Gillard; P J Vickers; S Sadowski; C Léveillé; J A Mancini; P Charleson; R A Dixon; A W Ford-Hutchinson; R Fortin
Journal:  Nature       Date:  1990-01-18       Impact factor: 49.962
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Journal:  Clin Rev Allergy Immunol       Date:  1999 Spring-Summer       Impact factor: 8.667

4.  Characterization of Epidermal Lipoxygenase Expression in Normal Human Skin and Tissue-Engineered Skin Substitutes.

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Journal:  J Histochem Cytochem       Date:  2018-07-09       Impact factor: 2.479

5.  Co-oxidation of NADH and NADPH by a mammalian 15-lipoxygenase: inhibition of lipoxygenase activity at near-physiological NADH concentrations.

Authors:  V B O'donnell; H Kühn
Journal:  Biochem J       Date:  1997-10-01       Impact factor: 3.857

Review 6.  Autophagy as a regulatory component of erythropoiesis.

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Journal:  Int J Mol Sci       Date:  2015-02-13       Impact factor: 5.923

Review 7.  A looming role of mitochondrial calcium in dictating the lung epithelial integrity and pathophysiology of lung diseases.

Authors:  Archita Ray; Ashish Jaiswal; Joytri Dutta; Sabita Singh; Ulaganathan Mabalirajan
Journal:  Mitochondrion       Date:  2020-09-21       Impact factor: 4.160
  7 in total

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