Literature DB >> 8132481

Analysis of type II polyketide beta-ketoacyl synthase specificity in Streptomyces coelicolor A3(2) by trans complementation of actinorhodin synthase mutants.

E S Kim1, D A Hopwood, D H Sherman.   

Abstract

Complementation of defined actinorhodin beta-ketoacyl synthase (KS) mutants by various other KS genes suggested that the ORF1-encoded KS may be relatively generalized in function, whereas the ORF2-encoded KS component may provide specificity in polyketide chain construction. Evidence for differential temporal-spatial expression of the actinorhodin and spore pigment KSs in Streptomyces coelicolor was obtained.

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Year:  1994        PMID： 8132481      PMCID： PMC205275          DOI： 10.1128/jb.176.6.1801-1804.1994

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  20 in total

1.  An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea.

Authors:  J Cortes; S F Haydock; G A Roberts; D J Bevitt; P F Leadlay
Journal:  Nature       Date:  1990-11-08       Impact factor: 49.962

2.  beta-Ketoacyl-ACP synthase I of Escherichia coli: nucleotide sequence of the fabB gene and identification of the cerulenin binding residue.

Authors:  S Kauppinen; M Siggaard-Andersen; P von Wettstein-Knowles
Journal:  Carlsberg Res Commun       Date:  1988

3.  Rat mammary gland fatty acid synthase: localization of the constituent domains and two functional polyadenylation/termination signals in the cDNA.

Authors:  M Schweizer; K Takabayashi; T Laux; K F Beck; R Schreglmann
Journal:  Nucleic Acids Res       Date:  1989-01-25       Impact factor: 16.971

4.  Molecular cloning and sequencing of cDNAs encoding the entire rat fatty acid synthase.

Authors:  C M Amy; A Witkowski; J Naggert; B Williams; Z Randhawa; S Smith
Journal:  Proc Natl Acad Sci U S A       Date:  1989-05       Impact factor: 11.205

Review 5.  The polymerase chain reaction.

Authors:  T J White; N Arnheim; H A Erlich
Journal:  Trends Genet       Date:  1989-06       Impact factor: 11.639

6.  Genetics of actinorhodin biosynthesis by Streptomyces coelicolor A3(2).

Authors:  B A Rudd; D A Hopwood
Journal:  J Gen Microbiol       Date:  1979-09

Review 7.  Polyketide synthesis: prospects for hybrid antibiotics.

Authors:  L Katz; S Donadio
Journal:  Annu Rev Microbiol       Date:  1993       Impact factor: 15.500

8.  The Streptomyces plasmid SCP2*: its functional analysis and development into useful cloning vectors.

Authors:  D J Lydiate; F Malpartida; D A Hopwood
Journal:  Gene       Date:  1985       Impact factor: 3.688

9.  Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tü22.

Authors:  D H Sherman; F Malpartida; M J Bibb; H M Kieser; M J Bibb; D A Hopwood
Journal:  EMBO J       Date:  1989-09       Impact factor: 11.598

10.  Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.

Authors:  M J Bibb; S Biró; H Motamedi; J F Collins; C R Hutchinson
Journal:  EMBO J       Date:  1989-09       Impact factor: 11.598
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  4 in total

1.  Developmental regulation of transcription of whiE, a locus specifying the polyketide spore pigment in Streptomyces coelicolor A3 (2)

Authors:  G H Kelemen; P Brian; K Flärdh; L Chamberlin; K F Chater; M J Buttner
Journal:  J Bacteriol       Date:  1998-05       Impact factor: 3.490

2.  Relationships between fatty acid and polyketide synthases from Streptomyces coelicolor A3(2): characterization of the fatty acid synthase acyl carrier protein.

Authors:  W P Revill; M J Bibb; D A Hopwood
Journal:  J Bacteriol       Date:  1996-10       Impact factor: 3.490

3.  Cloning, sequencing, and analysis of the griseusin polyketide synthase gene cluster from Streptomyces griseus.

Authors:  T W Yu; M J Bibb; W P Revill; D A Hopwood
Journal:  J Bacteriol       Date:  1994-05       Impact factor: 3.490

4.  Heterologous expression of an engineered biosynthetic pathway: functional dissection of type II polyketide synthase components in Streptomyces species.

Authors:  E S Kim; K D Cramer; A L Shreve; D H Sherman
Journal:  J Bacteriol       Date:  1995-03       Impact factor: 3.490
  4 in total

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