Literature DB >> 8132308

The prevention of infection in open fractures: an experimental study of the effect of fracture stability.

P Worlock1, R Slack, L Harvey, R Mawhinney.   

Abstract

An experimental model of a contaminated open fracture has been developed. This model has been used to test the hypothesis that stable fixation of a contaminated open fracture will reduce its susceptibility to infection. The tibiae of male New Zealand white rabbits were fractured and then fixed with either a dynamic compression plate (stable group) or a loose-fitting intramedullary rod (unstable group). The fracture site was then inoculated with a standard inoculum of Staphylococcus aureus. There were 20 rabbits in the stable group and osteomyelitis developed in seven (35 per cent); in the unstable group 15 (71 per cent) out of 21 animals developed osteomyelitis. This difference in infection rates was statistically significant (P < 0.02). This experimental study supports the concept of stabilization of open fractures in man.

Entities:  

Mesh：

Year:  1994        PMID： 8132308     DOI： 10.1016/0020-1383(94)90181-3

Source DB:  PubMed          Journal:  Injury        ISSN： 0020-1383            Impact factor:   2.586


  27 in total

1.  [Animal models of osteomyelitis].

Authors:  T Kälicke; U Schlegel; C Kraft; C Wingenfeld; G Muhr; S Arens
Journal:  Orthopade       Date:  2004-03       Impact factor: 1.087

2.  Incidence, microbiological findings, and clinical presentation of sternal wound infections after cardiac surgery with and without local gentamicin prophylaxis.

Authors:  O Friberg; R Svedjeholm; J Källman; B Söderquist
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2007-02       Impact factor: 3.267

Review 3.  [Osteosynthesis-associated infections : Epidemiology, definition and diagnosis].

Authors:  N Renz; S Feihl; C E Dlaska; M A Schütz; A Trampuz
Journal:  Unfallchirurg       Date:  2017-06       Impact factor: 1.000

4.  Biofilm Producing Staphylococcus epidermidis (RP62A Strain) Inhibits Osseous Integration Without Osteolysis and Histopathology in a Murine Septic Implant Model.

Authors:  Takuya Tomizawa; Masahiro Ishikawa; Sheila N Bello-Irizarry; Karen L de Mesy Bentley; Hiromu Ito; Stephen L Kates; John L Daiss; Christopher Beck; Shuichi Matsuda; Edward M Schwarz; Kohei Nishitani
Journal:  J Orthop Res       Date:  2019-11-19       Impact factor: 3.494

Review 5.  Nanomedicine for safe healing of bone trauma: Opportunities and challenges.

Authors:  Shahed Behzadi; Gaurav A Luther; Mitchel B Harris; Omid C Farokhzad; Morteza Mahmoudi
Journal:  Biomaterials       Date:  2017-09-04       Impact factor: 12.479

6.  Can Normal Fracture Healing Be Achieved When the Implant Is Retained on the Basis of Infection? An Experimental Animal Model.

Authors:  Fuat Bilgili; Halil Ibrahim Balci; Kayahan Karaytug; Kerim Sariyilmaz; Ata Can Atalar; Ergun Bozdag; Meral Tuna; Bilge Bilgic; Nezahat Gurler
Journal:  Clin Orthop Relat Res       Date:  2015-10       Impact factor: 4.176

7.  [Pathophysiology of posttraumatic osteitis].

Authors:  T Kälicke; F Kutscha-Lissberg; T M Frangen; G Muhr; S Arens
Journal:  Orthopade       Date:  2004-04       Impact factor: 1.087

8.  Infection in fracture fixation: can we influence infection rates through implant design?

Authors:  T Fintan Moriarty; U Schlegel; S Perren; R Geoff Richards
Journal:  J Mater Sci Mater Med       Date:  2009-10-20       Impact factor: 3.896

9.  Acute infections after fracture repair: management with hardware in place.

Authors:  Eric Rightmire; David Zurakowski; Mark Vrahas
Journal:  Clin Orthop Relat Res       Date:  2008-01-10       Impact factor: 4.176

10.  Treatment principles in the management of open fractures.

Authors:  William W Cross; Marc F Swiontkowski
Journal:  Indian J Orthop       Date:  2008-10       Impact factor: 1.251
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