Literature DB >> 8131845

The role of the ninth and tenth type III domains of human fibronectin in cell adhesion.

H J Mardon1, K E Grant.   

Abstract

Fibronectins (FN) contain sites, in addition to the cell recognition site RGD in the tenth type III domain (FIII10), that are required for adhesive activity. The role of FIII10 and the adjacent FIII9 was analysed in functional cell adhesion assays recombinant FIII domains in which the domain boundaries were strictly conserved. FIII9 had no adhesive activity. FIII10, and FIII9 plus FIII10 had less activity than FN, whereas the activity of FIII9-10 was similar to FN. We conclude that FIII9 acts synergistically with FIII10 in cell adhesion, and that this synergy is dependent upon the structural integrity of the FIII9-10 pair of domains.

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Year:  1994        PMID： 8131845     DOI： 10.1016/0014-5793(94)80137-1

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  25 in total

1.  Folding of beta-sandwich proteins: three-state transition of a fibronectin type III module.

Authors:  E Cota; J Clarke
Journal:  Protein Sci       Date:  2000-01       Impact factor: 6.725

2.  Guiding epithelial cell phenotypes with engineered integrin-specific recombinant fibronectin fragments.

Authors:  Ashley C Brown; Jessica A Rowe; Thomas H Barker
Journal:  Tissue Eng Part A       Date:  2010-12-12       Impact factor: 3.845

3.  Integrin α3β1 Binding to Fibronectin Is Dependent on the Ninth Type III Repeat.

Authors:  Ashley C Brown; Marilyn M Dysart; Kimberly C Clarke; Sarah E Stabenfeldt; Thomas H Barker
Journal:  J Biol Chem       Date:  2015-08-28       Impact factor: 5.157

4.  Enhancement of thrombogenesis by plasma fibronectin cross-linked to fibrin and assembled in platelet thrombi.

Authors:  Jaehyung Cho; Deane F Mosher
Journal:  Blood       Date:  2006-01-03       Impact factor: 22.113

5.  Structural requirements for biological activity of the ninth and tenth FIII domains of human fibronectin.

Authors:  R P Grant; C Spitzfaden; H Altroff; I D Campbell; H J Mardon
Journal:  J Biol Chem       Date:  1997-03-07       Impact factor: 5.157

6.  Detection of an Integrin-Binding Mechanoswitch within Fibronectin during Tissue Formation and Fibrosis.

Authors:  Lizhi Cao; John Nicosia; Jacqueline Larouche; Yuanyuan Zhang; Haylee Bachman; Ashley C Brown; Lars Holmgren; Thomas H Barker
Journal:  ACS Nano       Date:  2017-07-12       Impact factor: 15.881

7.  Interrogating protonated/deuterated fibronectin fragment layers adsorbed to titania by neutron reflectivity and their concomitant control over cell adhesion.

Authors:  Lisa McIntosh; Christine Whitelaw; Agata Rekas; Stephen A Holt; Christopher F van der Walle
Journal:  J R Soc Interface       Date:  2015-06-06       Impact factor: 4.118

8.  Interdomain tilt angle determines integrin-dependent function of the ninth and tenth FIII domains of human fibronectin.

Authors:  Harri Altroff; Robin Schlinkert; Christopher F van der Walle; Andrea Bernini; Iain D Campbell; Jörn M Werner; Helen J Mardon
Journal:  J Biol Chem       Date:  2004-10-12       Impact factor: 5.157

9.  Using self-assembled monolayers to model cell adhesion to the 9th and 10th type III domains of fibronectin.

Authors:  Jessica L Eisenberg; Justin L Piper; Milan Mrksich
Journal:  Langmuir       Date:  2009-12-15       Impact factor: 3.882

10.  Rapid refolding of a proline-rich all-beta-sheet fibronectin type III module.

Authors:  K W Plaxco; C Spitzfaden; I D Campbell; C M Dobson
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-01       Impact factor: 11.205
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