Literature DB >> 8130198

Determination of the secondary structure and folding topology of an RNA binding domain of mammalian hnRNP A1 protein using three-dimensional heteronuclear magnetic resonance spectroscopy.

D S Garrett1, P J Lodi, Y Shamoo, K R Williams, G M Clore, A M Gronenborn.   

Abstract

The secondary structure and folding topology of the first RNA binding domain of the human hnRNP A1 protein was determined by multidimensional heteronuclear NMR spectroscopy. The 92 amino acid long domain exhibits a beta alpha beta beta alpha beta folding pattern, arranged in a four-stranded antiparallel beta-sheet flanked by two alpha-helices, which is very similar to that found for other members of this family. Regions of marked variation between the structurally characterized RNA binding proteins of this class to date are mainly localized in the loops connecting the secondary structure elements.

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Year:  1994        PMID： 8130198     DOI： 10.1021/bi00176a015

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  14 in total

1.  Key residues revealed in a major conformational epitope of the U1-70K protein.

Authors:  E Welin Henriksson; M Wahren-Herlenius; I Lundberg; E Mellquist; I Pettersson
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-07       Impact factor: 11.205

2.  Anti-A2/RA33 autoantibodies are directed to the RNA binding region of the A2 protein of the heterogeneous nuclear ribonucleoprotein complex. Differential epitope recognition in rheumatoid arthritis, systemic lupus erythematosus, and mixed connective tissue disease.

Authors:  K Skriner; W H Sommergruber; V Tremmel; I Fischer; A Barta; J S Smolen; G Steiner
Journal:  J Clin Invest       Date:  1997-07-01       Impact factor: 14.808

Review 3.  Idiosyncrasies of hnRNP A1-RNA recognition: Can binding mode influence function.

Authors:  Jeffrey D Levengood; Blanton S Tolbert
Journal:  Semin Cell Dev Biol       Date:  2018-04-09       Impact factor: 7.727

Review 4.  Multiple RNA binding domains (RBDs) just don't add up.

Authors:  Y Shamoo; N Abdul-Manan; K R Williams
Journal:  Nucleic Acids Res       Date:  1995-03-11       Impact factor: 16.971

5.  RNA recognition by the joint action of two nucleolin RNA-binding domains: genetic analysis and structural modeling.

Authors:  P Bouvet; C Jain; J G Belasco; F Amalric; M Erard
Journal:  EMBO J       Date:  1997-09-01       Impact factor: 11.598

6.  Identification of N-terminal helix capping boxes by means of 13C chemical shifts.

Authors:  A M Gronenborn; G M Clore
Journal:  J Biomol NMR       Date:  1994-05       Impact factor: 2.835

7.  Protein phi and psi dihedral restraints determined from multidimensional hypersurface correlations of backbone chemical shifts and their use in the determination of protein tertiary structures.

Authors:  R D Beger; P H Bolton
Journal:  J Biomol NMR       Date:  1997-09       Impact factor: 2.835

8.  Combined use of 13C chemical shift and 1H alpha-13C alpha heteronuclear NOE data in monitoring a protein NMR structure refinement.

Authors:  B Celda; C Biamonti; M J Arnau; R Tejero; G T Montelione
Journal:  J Biomol NMR       Date:  1995-02       Impact factor: 2.835

9.  Solution structure of the two RNA recognition motifs of hnRNP A1 using segmental isotope labeling: how the relative orientation between RRMs influences the nucleic acid binding topology.

Authors:  Pierre Barraud; Frédéric H-T Allain
Journal:  J Biomol NMR       Date:  2012-12-18       Impact factor: 2.835

10.  Contribution of the tyrosines to the structure and function of the human U1A N-terminal RNA binding domain.

Authors:  J K Kranz; J Lu; K B Hall
Journal:  Protein Sci       Date:  1996-08       Impact factor: 6.725
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