D J Taylor1. 1. University Department of Medicine, University Hospital of South Manchester, West Didsbury, England.
Abstract
OBJECTIVE: To identify cytokines responsible for the increased levels of tumor necrosis factor receptor (TNFR) in the joints of patients with rheumatoid arthritis. METHODS: Antibodies to TNFR types were used both to inhibit ligand cell binding and to quantify released receptors in rheumatoid synovial fibroblasts. RESULTS: Binding by and shedding of the p75 TNFR was affected by interleukin-1 (IL-1), IL-4, and interferon-gamma. CONCLUSION: IL-1 could cause increased TNF alpha binding and TNFR shedding in inflamed joints.
OBJECTIVE: To identify cytokines responsible for the increased levels of tumor necrosis factor receptor (TNFR) in the joints of patients with rheumatoid arthritis. METHODS: Antibodies to TNFR types were used both to inhibit ligand cell binding and to quantify released receptors in rheumatoid synovial fibroblasts. RESULTS: Binding by and shedding of the p75 TNFR was affected by interleukin-1 (IL-1), IL-4, and interferon-gamma. CONCLUSION:IL-1 could cause increased TNF alpha binding and TNFR shedding in inflamed joints.