OBJECTIVE: To investigate leukocyte lipocortin-1 production in rheumatoid arthritis (RA). METHODS: Eight control and 8 RA subjects received 100 mg hydrocortisone intravenously. Leukocyte lipocortin-1 was measured by enzyme-linked immunosorbent assay. RESULTS: Hydrocortisone induced significant increases in lipocortin-1 production by control mononuclear cells (MNC) (P = 0.006 versus baseline) but not by RA MNC (P = 0.44 versus baseline). Peak lipocortin-1 levels in control MNC were significantly higher than those in RA MNC (P = 0.014). CONCLUSION: These results indicate that glucocorticoid-induced MNC lipocortin-1 production is impaired in RA.
OBJECTIVE: To investigate leukocyte lipocortin-1 production in rheumatoid arthritis (RA). METHODS: Eight control and 8 RA subjects received 100 mg hydrocortisone intravenously. Leukocyte lipocortin-1 was measured by enzyme-linked immunosorbent assay. RESULTS:Hydrocortisone induced significant increases in lipocortin-1 production by control mononuclear cells (MNC) (P = 0.006 versus baseline) but not by RA MNC (P = 0.44 versus baseline). Peak lipocortin-1 levels in control MNC were significantly higher than those in RA MNC (P = 0.014). CONCLUSION: These results indicate that glucocorticoid-induced MNC lipocortin-1 production is impaired in RA.
Authors: M I Rodríguez-García; J A Fernández; A Rodríguez; M P Fernández; C Gutierrez; J C Torre-Alonso Journal: Ann Rheum Dis Date: 1996-12 Impact factor: 19.103
Authors: N J Goulding; J Dixey; E F Morand; R A Dodds; L S Wilkinson; A A Pitsillides; J C Edwards Journal: Ann Rheum Dis Date: 1995-10 Impact factor: 19.103
Authors: Ida Bergström; Anna K Lundberg; Simon Jönsson; Eva Särndahl; Jan Ernerudh; Lena Jonasson Journal: PLoS One Date: 2017-03-22 Impact factor: 3.240