| Literature DB >> 8128627 |
I Lowy1, M Caruso, S P Goff, D Klatzmann.
Abstract
In this report, we provide evidence that the cellular thymidine kinase activity is required for the inhibition of HIV replication by zidovudine (AZT) in lymphocytes. The HSV-1 thymidine kinase protein is not able to substitute for the cellular enzyme, in accord with in vitro data that AZT is poorly phosphorylated by the HSV-derived activity.Entities:
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Year: 1994 PMID： 8128627 DOI： 10.1006/viro.1994.1185
Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616