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Literature DB >> 8127684

Synthesis of phosphorothioate-methylphosphonate oligonucleotide co-polymers.

L Zhou¹, A M Morocho, B C Chen, J S Cohen.

Abstract

We describe the synthesis and characterization of novel phosphorothioate-methylphosphonate backbone-modified oligodeoxynucleotide co-polymers. These may have potential use as antisense constructs.

Entities: Chemical

Mesh：

Substances：

Year: 1994 PMID： 8127684 PMCID： PMC523603 DOI： 10.1093/nar/22.3.453

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

11 in total

Review 1. Oligodeoxynucleotides as antisense inhibitors of gene expression.

Authors: M K Ghosh; J S Cohen
Journal: Prog Nucleic Acid Res Mol Biol Date: 1992

2. RNase H cleavage of RNA hybridized to oligonucleotides containing methylphosphonate, phosphorothioate and phosphodiester bonds.

Authors: P J Furdon; Z Dominski; R Kole
Journal: Nucleic Acids Res Date: 1989-11-25 Impact factor: 16.971

3. Preparation of oligodeoxyribonucleoside methylphosphonates on a polystyrene support.

Authors: P S Miller; C H Agris; A Murakami; P M Reddy; S A Spitz; P O Ts'o
Journal: Nucleic Acids Res Date: 1983-09-24 Impact factor: 16.971

Review 4. A new approach to chemotherapy based on molecular biology and nucleic acid chemistry: Matagen (masking tape for gene expression).

Authors: P S Miller; P O Ts'o
Journal: Anticancer Drug Des Date: 1987-10

5. Effects of phosphorothioate capping on antisense oligonucleotide stability, hybridization and antiviral efficacy versus herpes simplex virus infection.

Authors: G D Hoke; K Draper; S M Freier; C Gonzalez; V B Driver; M C Zounes; D J Ecker
Journal: Nucleic Acids Res Date: 1991-10-25 Impact factor: 16.971

6. Phosphorothioate-phosphodiester oligonucleotide co-polymers: assessment for antisense application.

Authors: M K Ghosh; K Ghosh; J S Cohen
Journal: Anticancer Drug Des Date: 1993-02

7. Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus.

Authors: M Matsukura; K Shinozuka; G Zon; H Mitsuya; M Reitz; J S Cohen; S Broder
Journal: Proc Natl Acad Sci U S A Date: 1987-11 Impact factor: 11.205

Synthesis of phosphorothioate-methylphosphonate oligonucleotide co-polymers.

Review 1. Oligodeoxynucleotides as antisense inhibitors of gene expression.

2. RNase H cleavage of RNA hybridized to oligonucleotides containing methylphosphonate, phosphorothioate and phosphodiester bonds.

3. Preparation of oligodeoxyribonucleoside methylphosphonates on a polystyrene support.

Review 4. A new approach to chemotherapy based on molecular biology and nucleic acid chemistry: Matagen (masking tape for gene expression).

5. Effects of phosphorothioate capping on antisense oligonucleotide stability, hybridization and antiviral efficacy versus herpes simplex virus infection.

6. Phosphorothioate-phosphodiester oligonucleotide co-polymers: assessment for antisense application.

7. Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus.

8. Physicochemical properties of phosphorothioate oligodeoxynucleotides.

9. Cellular uptake and subcellular distribution of phosphorothioate oligonucleotides into cultured cells.

10. Enhanced RNase H activity with methylphosphonodiester/phosphodiester chimeric antisense oligodeoxynucleotides.

Review 1. Preclinical and clinical pharmacology of antisense oligonucleotides.

2. Radiolabeled oligonucleotides for antisense imaging.