| Literature DB >> 8127365 |
X Xie1, D H Harrison, I Schlichting, R M Sweet, V N Kalabokis, A G Szent-Györgyi, C Cohen.
Abstract
The regulatory domain of scallop myosin is a three-chain protein complex that switches on this motor in response to Ca2+ binding. This domain has been crystallized and the structure solved to 2.8 A resolution. Side-chain interactions link the two light chains in tandem to adjacent segments of the heavy chain bearing the IQ-sequence motif. The Ca(2+)-binding site is a novel EF-hand motif on the essential light chain and is stabilized by linkages involving the heavy chain and both light chains, accounting for the requirement of all three chains for Ca2+ binding and regulation in the intact myosin molecule.Entities:
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Year: 1994 PMID： 8127365 DOI： 10.1038/368306a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962