Literature DB >> 812582

Phenformin and lactic acidosis.

P H Wise, M Chapman, D W Thomas, A R Clarkson, P E Harding, J B Edwards.   

Abstract

Thirty-eight patients who presented with diabetes and a changed state of consciousness satisfied the criteria for lactic acidosis. Sixteen patients were non-ketotic, and 15 of these were receiving phenformin on admission. In all but one of these 15 patients, however, additional renal or cardiovascular abnormalities, or both, could be identified, which supported a multifactorial aetiology for lactic acidosis. Advanced age and cardiovascular and renal disease are absolute contraindications to the use of phenformin in diabetics.

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Year:  1976        PMID： 812582      PMCID： PMC1638317          DOI： 10.1136/bmj.1.6001.70

Source DB:  PubMed          Journal:  Br Med J        ISSN： 0007-1447


  8 in total

1.  Metformin and lactic acidosis.

Authors:  E G Lebacq; A Tirzmalis
Journal:  Lancet       Date:  1972-02-05       Impact factor: 79.321

2.  Lactic acidosis: recovery associated with use of peritoneal dialysis.

Authors:  J M Sheppard; J R Lawrence; R C Oon; D W Thomas; P G Row; P H Wise
Journal:  Aust N Z J Med       Date:  1972-11

3.  The relation between phenformin therapy and lactic acidosis.

Authors:  R D Cohen; J D Ward; A J Brain; C R Murray; T M Savege; R A Iles
Journal:  Diabetologia       Date:  1973-02       Impact factor: 10.122

4.  An evaluation of Ketostix strips.

Authors:  P J Watkins; M G FitzGerald
Journal:  Diabetes       Date:  1968-06       Impact factor: 9.461

5.  Fatal self-poisoning with phenformin.

Authors:  J P Bingle; G W Storey; J M Winter
Journal:  Br Med J       Date:  1970-09-26

6.  The treatment of lactic acidosis in the diabetic patient by peritoneal dialysis using sodium acetate. A report of two cases.

Authors:  J C Hayat
Journal:  Diabetologia       Date:  1974-10       Impact factor: 10.122

7.  Rapid enzymatic measurement of blood lactate and pyruvate. Use and significance of metaphosphoric acid as a common precipitant.

Authors:  E P Marbach; M H Weil
Journal:  Clin Chem       Date:  1967-04       Impact factor: 8.327

8.  The liver and lactic acidosis.

Authors:  M N Berry
Journal:  Proc R Soc Med       Date:  1967-12
  8 in total
  8 in total

1.  Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET.

Authors:  Avner Schlessinger; Ethan Geier; Hao Fan; John J Irwin; Brian K Shoichet; Kathleen M Giacomini; Andrej Sali
Journal:  Proc Natl Acad Sci U S A       Date:  2011-09-01       Impact factor: 11.205

2.  Biguanides and lactic acidosis.

Authors:  P J Phillips; D W Thomas; P E Harding
Journal:  Br Med J       Date:  1977-01-22

3.  Metformin-induced lactic acidosis in the presence of acute renal failure.

Authors:  R Assan; C Heuclin; D Ganeval; C Bismuth; J George; J R Girard
Journal:  Diabetologia       Date:  1977-05       Impact factor: 10.122

4.  An experimental model of phenformin-induced lactic acidosis in rats.

Authors:  R Assan; C Heuclin; J R Girard
Journal:  Diabetologia       Date:  1978-04       Impact factor: 10.122

5.  Can phenformin-induced lactic acidosis be prevented?

Authors:  E A Gale; R B Tattersall
Journal:  Br Med J       Date:  1976-10-23

6.  Biguanide-induced lactic acidosis in Finland.

Authors:  T Korhonen; J Idänpään-Heikkilä; A Aro
Journal:  Eur J Clin Pharmacol       Date:  1979-07       Impact factor: 2.953

Review 7.  Lactic acidosis in biguanide-treated diabetics: a review of 330 cases.

Authors:  D Luft; R M Schmülling; M Eggstein
Journal:  Diabetologia       Date:  1978-02       Impact factor: 10.122

8.  [The effect of combined therapy with buformin and dichloracetate on blood lactate concentrations in diabetics].

Authors:  E Standl; H U Janka; A Standl; M Haslbeck; H Mehnert
Journal:  Klin Wochenschr       Date:  1977-10-01
  8 in total

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