Literature DB >> 8124920

Concurrent acute megaloblastic anaemia and pneumonitis: a severe side-effect of low-dose methotrexate therapy during rheumatoid arthritis.

G Bolla1, P Disdier, J R Harle, D Verrot, P J Weiller.   

Abstract

In a patient suffering from rheumatoid arthritis, we report the first simultaneous occurrence of two side effects of low-dose methotrexate: an acute megaloblastic anaemia and a pneumonitis. A combination of methotrexate suspension, folinic acid and corticosteroids led to recovery. The correlation between the haematologic and pneumologic toxicity is discussed.

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Year:  1993        PMID： 8124920     DOI： 10.1007/bf02231787

Source DB:  PubMed          Journal:  Clin Rheumatol        ISSN： 0770-3198            Impact factor:   2.980


  10 in total

1.  Exacerbation of rheumatoid arthritis in patients treated with methotrexate after administration of folinic acid.

Authors:  D A Joyce; R K Will; D M Hoffman; B Laing; S J Blackbourn
Journal:  Ann Rheum Dis       Date:  1991-12       Impact factor: 19.103

2.  Successful reintroduction of methotrexate after pneumonitis in two patients with rheumatoid arthritis.

Authors:  N J Cook; G J Carroll
Journal:  Ann Rheum Dis       Date:  1992-02       Impact factor: 19.103

3.  The effect of folic acid supplementation on the toxicity of low-dose methotrexate in patients with rheumatoid arthritis.

Authors:  S L Morgan; J E Baggott; W H Vaughn; P K Young; J V Austin; C L Krumdieck; G S Alarcón
Journal:  Arthritis Rheum       Date:  1990-01

Review 4.  Long-term methotrexate therapy for rheumatoid arthritis.

Authors:  C J Scully; C J Anderson; G W Cannon
Journal:  Semin Arthritis Rheum       Date:  1991-04       Impact factor: 5.532

5.  Folate supplementation in methotrexate-treated rheumatoid arthritis patients.

Authors:  K A Stewart; A H Mackenzie; J D Clough; W S Wilke
Journal:  Semin Arthritis Rheum       Date:  1991-04       Impact factor: 5.532

6.  Elevated mean corpuscular volume as a predictor of hematologic toxicity due to methotrexate therapy.

Authors:  M E Weinblatt; P Fraser
Journal:  Arthritis Rheum       Date:  1989-12

Review 7.  Methotrexate: mechanism of action in rheumatoid arthritis.

Authors:  R Segal; M Yaron; B Tartakovsky
Journal:  Semin Arthritis Rheum       Date:  1990-12       Impact factor: 5.532

Review 8.  Endogenous mutagens and the causes of aging and cancer.

Authors:  B N Ames; L S Gold
Journal:  Mutat Res       Date:  1991 Sep-Oct       Impact factor: 2.433

9.  Carcinoma of the prostate presenting as interstitial lung disease.

Authors:  O Cohen; L Leibovici; A I Wysenbeek
Journal:  Respiration       Date:  1987       Impact factor: 3.580

10.  Serum folate and vitamin B12 levels in patients with small cell lung cancer.

Authors:  G H Clamon; R Feld; W K Evans; R S Weiner; B S Kramer; L L Lininger; L B Gardner; E C Wolfe; W D DeWys; F A Hoffman
Journal:  Cancer       Date:  1984-01-15       Impact factor: 6.860
  10 in total

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