Literature DB >> 8124767

Synthesis and antitumor activities of prodrugs of benzoylphenylureas.

H Okada1, T Koyanagi, N Yamada.   

Abstract

Various benzoylphenylurea derivatives were synthesized as candidate prodrugs and their antitumor activities were examined in vivo against P388 leukemia. All of the prodrugs were soluble in most organic solvents and showed good antitumor activities against P388 leukemia cells in mice when dosed intraperitoneally or orally.

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Year:  1994        PMID: 8124767     DOI: 10.1248/cpb.42.57

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN: 0009-2363            Impact factor:   1.645


  3 in total

1.  URD12: A urea derivative with marked antitumor activities.

Authors:  Ai-Yun Wang; Yin Lu; Hai-Liang Zhu; Qing-Cai Jiao
Journal:  Oncol Lett       Date:  2011-11-08       Impact factor: 2.967

2.  Phase I study of continuous weekly dosing of dimethylamino benzoylphenylurea (BPU) in patients with solid tumours.

Authors:  Wells A Messersmith; Michelle A Rudek; Sharyn D Baker; Ming Zhao; Connie Collins; A Dimitrios Colevas; Ross C Donehower; Michael A Carducci; Antonio C Wolff
Journal:  Eur J Cancer       Date:  2006-11-03       Impact factor: 9.162

3.  Synthesis and Antitumor Activities of Chiral Dipeptide Thioureas Containing an Alpha-Aminophosphonate Moiety.

Authors:  Jingzi Liu; Peng Liao; Junfeng Hu; Hong Zhu; Yonglin Wang; Yongjun Li; Yan Li; Bin He
Journal:  Molecules       Date:  2017-02-16       Impact factor: 4.411

  3 in total

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