[5-fluorouracil in goniotrepanation with poor prognosis. Results of 1-year follow-up].

14 eyes of 14 patients with medically untreatable glaucoma and extremely bad surgical prognosis because of young age, secondary glaucomas or following previous surgery were treated by means of goniotrephination with a scleral flap and a fornix-based conjunctival flap. Postoperatively, all eyes received 5 mg 5-fluorouracil in 0.5 ml NaCl 0.9% subconjunctivally daily for 7 days and weekly for another 6 weeks. IOP was lowered in all eyes from 33.9 +/- 5.0 mmHg preoperatively to 15.6 +/- 8.4 mmHg 1 year postoperatively. 71% of eyes were IOP controlled without further therapy. Results were unfavourable in eyes with irido-corneo-endothelial syndrome. Local side effects were less frequent than described previously, possible due to the reduced but prolonged administration of 5-fluorouracil. Also, all eyes received corneal supportive therapy with hyaluronic acid and polyvinyl alcohol.