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Literature DB >> 8123620

Regional variation and age-related changes of lysosomal enzymes in the human retinal pigment epithelium.

M Boulton¹, P Moriarty, J Jarvis-Evans, B Marcyniuk.

Abstract

In this study the activities of two lysosomal enzymes in retinal pigment epithelial (RPE) cells isolated from three regions of the human fundus were examined: the macula, the nasal midzone, and the periphery. The results obtained showed that the activities of acid phosphatase and cathepsin D were significantly higher in the RPE cells derived from the macular region when compared with those in the periphery. The values for the midzone appeared to be intermediate between the other two regions. Furthermore, the overall activity of both enzymes increased as a function of age.

Entities: Disease Gene Species

Mesh：

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Year: 1994 PMID： 8123620 PMCID： PMC504714 DOI： 10.1136/bjo.78.2.125

Source DB: PubMed Journal: Br J Ophthalmol ISSN： 0007-1161 Impact factor: 4.638

24 in total

1. Aging of the human retina. Differential loss of neurons and retinal pigment epithelial cells.

Authors: H Gao; J G Hollyfield
Journal: Invest Ophthalmol Vis Sci Date: 1992-01 Impact factor: 4.799

2. Autography in visual cells and pigment epithelium.

Authors: C E Remé
Journal: Invest Ophthalmol Vis Sci Date: 1977-09 Impact factor: 4.799

Review 3. Non-enzymatic, post-translational, amino acid modifications in ageing. A brief review.

Authors: J H McKerrow
Journal: Mech Ageing Dev Date: 1979-07 Impact factor: 5.432

4. Electron microscopical studies on rat brain neurons. Localization of acid phosphatase and mode of formation of lipofuscin bodies.

Authors: U Brunk; J L Ericsson
Journal: J Ultrastruct Res Date: 1972-01

5. The degradation of the photoreceptor outer segment within the pigment epithelial cell of rat retina.

Authors: T Ishikawa; E Yamada
Journal: J Electron Microsc (Tokyo) Date: 1970

6. Development of the human retinal pigment epithelium and the posterior segment.

Authors: B W Streeten
Journal: Arch Ophthalmol Date: 1969-03

7. Cyclic nucleotides vary by area in the retina and pigmented epithelium of the human and monkey.

Authors: D A Newsome; R T Fletcher; G J Chader
Journal: Invest Ophthalmol Vis Sci Date: 1980-08 Impact factor: 4.799

8. Altered phosphoglycerate kinase in aging rats.

Authors: H K Sharma; H R Prasanna; M Rothstein
Journal: J Biol Chem Date: 1980-06-10 Impact factor: 5.157

9. Lipofuscin and melanin of human retinal pigment epithelium. Fluorescence, enzyme cytochemical, and ultrastructural studies.

Authors: L Feeney
Journal: Invest Ophthalmol Vis Sci Date: 1978-07 Impact factor: 4.799

10. The topography and age relationship of lipofuscin concentration in the retinal pigment epithelium.

Authors: G L Wing; G C Blanchard; J J Weiter
Journal: Invest Ophthalmol Vis Sci Date: 1978-07 Impact factor: 4.799

15 in total

1. "Oxidative protector" enzymes in the macular retinal pigment epithelium of aging eyes and eyes with age-related macular degeneration.

Authors: R N Frank
Journal: Trans Am Ophthalmol Soc Date: 1998

Review 2. Advanced glycation: an important pathological event in diabetic and age related ocular disease.

Authors: A W Stitt
Journal: Br J Ophthalmol Date: 2001-06 Impact factor: 4.638

3. Modulation of cathepsin D activity in retinal pigment epithelial cells.

Authors: P E Rakoczy; C M Lai; M Baines; S Di Grandi; J H Fitton; I J Constable
Journal: Biochem J Date: 1997-06-15 Impact factor: 3.857

4. A role for vitamin A in the formation of ocular lipofuscin.

Authors: J Wassell; M Boulton
Journal: Br J Ophthalmol Date: 1997-10 Impact factor: 4.638

Review 5. Dietary hyperglycemia, glycemic index and metabolic retinal diseases.

Authors: Chung-Jung Chiu; Allen Taylor
Journal: Prog Retin Eye Res Date: 2010-09-22 Impact factor: 21.198

6. Varied expression of functionally important genes of RPE and choroid in the macula and in the periphery of normal human eyes.

Authors: Norbert Kociok; Antonia M Joussen
Journal: Graefes Arch Clin Exp Ophthalmol Date: 2006-04-06 Impact factor: 3.117

7. Proteome Profiling of Vitreoretinal Diseases by Cluster Analysis.

Authors: Tomomi Shitama; Hideyuki Hayashi; Sumiyo Noge; Eiichi Uchio; Kenji Oshima; Hisao Haniu; Nobuaki Takemori; Naoka Komori; Hiroyuki Matsumoto
Journal: Proteomics Clin Appl Date: 2008-09 Impact factor: 3.494

8. Melanoregulin (MREG) modulates lysosome function in pigment epithelial cells.

Authors: Monika Damek-Poprawa; Tanja Diemer; Vanda S Lopes; Concepción Lillo; Dawn C Harper; Michael S Marks; Yalin Wu; Janet R Sparrow; Rivka A Rachel; David S Williams; Kathleen Boesze-Battaglia
Journal: J Biol Chem Date: 2009-02-23 Impact factor: 5.157

9. Age-related changes in the retinal pigment epithelium (RPE).

Authors: Xiaorong Gu; Nikolas J Neric; John S Crabb; John W Crabb; Sanjoy K Bhattacharya; Mary E Rayborn; Joe G Hollyfield; Vera L Bonilha
Journal: PLoS One Date: 2012-06-11 Impact factor: 3.240

10. Changes in retinal pigment epithelium related to cigarette smoke: possible relevance to smoking as a risk factor for age-related macular degeneration.

Authors: Ai Ling Wang; Thomas J Lukas; Ming Yuan; Nga Du; James T Handa; Arthur H Neufeld
Journal: PLoS One Date: 2009-04-24 Impact factor: 3.240