Literature DB >> 8121638

Cellular localization of serotonin transporter mRNA in the rat brain.

M Fujita1, S Shimada, H Maeno, T Nishimura, M Tohyama.   

Abstract

Expression of serotonin (5-hydroxytryptamine, 5-HT) transporter mRNA in the rat brain was examined by in situ hybridization histochemistry with a synthetic oligonucleotide probe. 5-HT transporter mRNA was expressed in neurons in most of the raphe nuclei. The dorsal and median raphe nuclei contained intensely labeled neurons, while the caudal linear nucleus, raphe magnus nucleus, raphe pontis nucleus, raphe pallidus nucleus and the raphe obscurus nucleus contained weakly or moderately labeled neurons. The localization pattern of the 5-HT transporter mRNA-positive neurons coincides fairly well with that of 5-HT-immunoreactive neurons, indicating that 5-HT transporter is primarily located in serotonergic neurons.

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Year:  1993        PMID： 8121638     DOI： 10.1016/0304-3940(93)90559-4

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  13 in total

1.  Corticosteroids regulate 5-HT(1A) but not 5-HT(1B) receptor mRNA in rat hippocampus.

Authors:  J F Neumaier; T J Sexton; M W Hamblin; S G Beck
Journal:  Brain Res Mol Brain Res       Date:  2000-10-20

2.  Synthesis, radiosynthesis, and biological evaluation of fluorine-18-labeled 2beta-carbo(fluoroalkoxy)-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography.

Authors:  Jeffrey S Stehouwer; Nachwa Jarkas; Fanxing Zeng; Ronald J Voll; Larry Williams; Vernon M Camp; Eugene J Malveaux; John R Votaw; Leonard Howell; Michael J Owens; Mark M Goodman
Journal:  J Med Chem       Date:  2008-12-25       Impact factor: 7.446

3.  Effects of chronic caffeine exposure during adolescence and subsequent acute caffeine challenge during adulthood on rat brain serotonergic systems.

Authors:  M R Arnold; P H Williams; J A McArthur; A R Archuleta; C E O'Neill; J E Hassell; D G Smith; R K Bachtell; C A Lowry
Journal:  Neuropharmacology       Date:  2018-12-20       Impact factor: 5.250

4.  Fluorine-18 Radiolabeled PET Tracers for Imaging Monoamine Transporters: Dopamine, Serotonin, and Norepinephrine.

Authors:  Jeffrey S Stehouwer; Mark M Goodman
Journal:  PET Clin       Date:  2009-01

5.  Long-term exposure to high corticosterone levels attenuates serotonin responses in rat hippocampal CA1 neurons.

Authors:  Y J Karten; S M Nair; L van Essen; R Sibug; M Joëls
Journal:  Proc Natl Acad Sci U S A       Date:  1999-11-09       Impact factor: 11.205

6.  A PET study on regional coexpression of 5-HT1A receptors and 5-HTT in the human brain.

Authors:  Johan Lundberg; Jacqueline Borg; Christer Halldin; Lars Farde
Journal:  Psychopharmacology (Berl)       Date:  2007-09-15       Impact factor: 4.530

7.  Chronic social defeat up-regulates expression of the serotonin transporter in rat dorsal raphe nucleus and projection regions in a glucocorticoid-dependent manner.

Authors:  Jia Zhang; Yan Fan; Ying Li; Hobart Zhu; Liang Wang; Meng-Yang Zhu
Journal:  J Neurochem       Date:  2012-11-07       Impact factor: 5.372

8.  Adverse early life experience and social stress during adulthood interact to increase serotonin transporter mRNA expression.

Authors:  Katherine L Gardner; Matthew W Hale; Stafford L Lightman; Paul M Plotsky; Christopher A Lowry
Journal:  Brain Res       Date:  2009-09-23       Impact factor: 3.252

9.  Development × environment interactions control tph2 mRNA expression.

Authors:  J L Lukkes; J M Kopelman; N C Donner; M W Hale; C A Lowry
Journal:  Neuroscience       Date:  2013-02-09       Impact factor: 3.590

10.  Compartmental modeling of 11C-HOMADAM binding to the serotonin transporter in the healthy human brain.

Authors:  Jonathon A Nye; John R Votaw; Nachwa Jarkas; David Purselle; Vernon Camp; James D Bremner; Clinton D Kilts; Charles B Nemeroff; Mark M Goodman
Journal:  J Nucl Med       Date:  2008-12       Impact factor: 10.057
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