Literature DB >> 8121627

Selective loss of pallidal dopamine D2 receptor density in hepatic encephalopathy.

D D Mousseau1, P Perney, G P Layrargues, R F Butterworth.   

Abstract

The binding parameters of [3H]SCH 23390 and [3H]spiperone (radioligands for dopamine D1 and D2 receptors, respectively) were investigated in autopsied frontal cortex, caudate nucleus and globus pallidus/putamen of cirrhotic patients who died in hepatic coma as well as in age- and sex-matched controls. Specific [3H]SCH 23390 binding site densities were unchanged in all regions; in contrast, specific [3H]spiperone binding site density was decreased (by 44%, P < 0.001) in the globus pallidus/putamen of patients with HE. Decreased densities of pallidal D2 binding sites could relate to the motor dysfunctions commonly encountered in human HE.

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Year:  1993        PMID： 8121627     DOI： 10.1016/0304-3940(93)90593-a

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  24 in total

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Review 2.  Neurotransmitter dysfunction in hepatic encephalopathy: new approaches and new findings.

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Review 3.  Clinical significance of basal ganglia alterations at brain MRI and 1H MRS in cirrhosis and role in the pathogenesis of hepatic encephalopathy.

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Review 4.  The basal ganglia and portal-systemic encephalopathy.

Authors:  K Weissenborn; H Kolbe
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Review 5.  Neural synchronization in hepatic encephalopathy.

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Review 6.  Neuronal cell death in hepatic encephalopathy.

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7.  Association of dopamine receptor gene polymorphisms with the clinical course of Wilson disease.

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8.  Release of [3H]dopamine from striatal and cerebral cortical slices from rats with thioacetamide-induced hepatic encephalopathy: different responses to stimulation by potassium ions and agonists of ionotropic glutamate receptors.

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Journal:  Neurochem Res       Date:  1997-02       Impact factor: 3.996

Review 9.  Pathophysiology of alcoholic brain damage: synergistic effects of ethanol, thiamine deficiency and alcoholic liver disease.

Authors:  R F Butterworth
Journal:  Metab Brain Dis       Date:  1995-03       Impact factor: 3.584

10.  Accumulation of manganese and copper in pallidum of cirrhotic patients: role in the pathogenesis of hepatic encephalopathy?

Authors:  G P Layrargues; D Shapcott; L Spahr; R F Butterworth
Journal:  Metab Brain Dis       Date:  1995-12       Impact factor: 3.584
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