Literature DB >> 812093

Evidence of homologous relationship between thermolysin and neutral protease A of Bacillus subtilis.

P L Levy, M K Pangburn, Y Burstein, L H Ericsson, H Neurath, K A Walsh.   

Abstract

A comparison of the partial amino-acid sequence of neutral protease A from Bacillus subtilis with the structure of thermolysin (EC 3.4.24.4) from Bacillus thermoproteolyticus reveals that these two proteins are homologous. Of 171 residues placed in neutral protease (54% of the sequence), 83 residues (49%) occur in identical positions in thermolysin, and include nine of the 13 residues previously identified as components of the active site of thermolysin. This similarity provides support for the hypothesis that the two enzymes have similar three-dimensional structures and a common mechanism of action. Since these enzymes differ markedly in their resistance to heat inactivation, a comparison of their structures may eventually provide a chemical basis for explaining the differences in their thermal stability.

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Year:  1975        PMID： 812093      PMCID： PMC388717          DOI： 10.1073/pnas.72.11.4341

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  17 in total

1.  N- AND C-TERMINAL RESIDUES IN BAKER'S YEAST CYTOCHROME C.

Authors:  Y YAOI; K TITANI; K NARITA
Journal:  J Biochem       Date:  1964-09       Impact factor: 3.387

2.  Determination of the tryptophan content of proteins by ion exchange chromatography of alkaline hydrolysates.

Authors:  T E Hugli; S Moore
Journal:  J Biol Chem       Date:  1972-05-10       Impact factor: 5.157

3.  The cooperative binding of two calcium ions to the double site of apothermolysin.

Authors:  G Voordouw; R S Roche
Journal:  Biochemistry       Date:  1974-11-19       Impact factor: 3.162

4.  Neutral proteases of the genus Bacillus.

Authors:  L Keay
Journal:  Biochem Biophys Res Commun       Date:  1969-07-23       Impact factor: 3.575

5.  Thermolysin: a zinc metalloenzyme.

Authors:  S A Latt; B Holmquist; B L Vallee
Journal:  Biochem Biophys Res Commun       Date:  1969-10-08       Impact factor: 3.575

6.  Affinity chromatography of thermolysin and of neutral proteases from B. subtilis.

Authors:  M K Pangburn; Y Burstein; P H Morgan; K A Walsh; H Neurath
Journal:  Biochem Biophys Res Commun       Date:  1973-09-05       Impact factor: 3.575

7.  The conformation of thermolysin.

Authors:  B W Matthews; L H Weaver; W R Kester
Journal:  J Biol Chem       Date:  1974-12-25       Impact factor: 5.157

8.  Studies on the role of calcium in thermolysin.

Authors:  J Feder; L R Garrett; B S Wildi
Journal:  Biochemistry       Date:  1971-11-23       Impact factor: 3.162

9.  Staphylococcal protease: a proteolytic enzyme specific for glutamoyl bonds.

Authors:  J Houmard; G R Drapeau
Journal:  Proc Natl Acad Sci U S A       Date:  1972-12       Impact factor: 11.205

10.  Control of 5-aminolaevulinate synthetase activity in Rhodopseudomonas spheroides. The involvement of sulphur metabolism.

Authors:  A Neuberger; J D Sandy; G H Tait
Journal:  Biochem J       Date:  1973-11       Impact factor: 3.857
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  10 in total

1.  Purification and characterization of acidolysin, an acidic metalloprotease produced by Clostridium acetobutylicum ATCC 824.

Authors:  C Croux; V Paquet; G Goma; P Soucaille
Journal:  Appl Environ Microbiol       Date:  1990-12       Impact factor: 4.792

Review 2.  Bacterial extracellular zinc-containing metalloproteases.

Authors:  C C Häse; R A Finkelstein
Journal:  Microbiol Rev       Date:  1993-12

3.  Structural gene and complete amino acid sequence of Pseudomonas aeruginosa IFO 3455 elastase.

Authors:  J Fukushima; S Yamamoto; K Morihara; Y Atsumi; H Takeuchi; S Kawamoto; K Okuda
Journal:  J Bacteriol       Date:  1989-03       Impact factor: 3.490

Review 4.  Extracellular enzyme synthesis in the genus Bacillus.

Authors:  F G Priest
Journal:  Bacteriol Rev       Date:  1977-09

5.  Extracellular and membrane-bound proteases from Bacillus subtilis.

Authors:  P Mäntsälä; H Zalkin
Journal:  J Bacteriol       Date:  1980-02       Impact factor: 3.490

6.  Genes for alkaline protease and neutral protease from Bacillus amyloliquefaciens contain a large open reading frame between the regions coding for signal sequence and mature protein.

Authors:  N Vasantha; L D Thompson; C Rhodes; C Banner; J Nagle; D Filpula
Journal:  J Bacteriol       Date:  1984-09       Impact factor: 3.490

7.  Cloning of the neutral protease gene of Bacillus subtilis and the use of the cloned gene to create an in vitro-derived deletion mutation.

Authors:  M Y Yang; E Ferrari; D J Henner
Journal:  J Bacteriol       Date:  1984-10       Impact factor: 3.490

8.  Cloning and sequencing of Serratia protease gene.

Authors:  K Nakahama; K Yoshimura; R Marumoto; M Kikuchi; I S Lee; T Hase; H Matsubara
Journal:  Nucleic Acids Res       Date:  1986-07-25       Impact factor: 16.971

9.  The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

Authors:  H E Van Wart; H Birkedal-Hansen
Journal:  Proc Natl Acad Sci U S A       Date:  1990-07       Impact factor: 11.205

10.  A fluorimetric study of the role of calcium ions in the stability of thermolysin.

Authors:  A Fontana; C Vita; E Boccu; F M Veronese
Journal:  Biochem J       Date:  1977-09-01       Impact factor: 3.857
  10 in total

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