Literature DB >> 812007

Isoniazid as an inhibitor of primidone metabolism.

G Sutton, H J Kupferberg.   

Abstract

Isoniazid inhibited the metabolism of primidone in a patient with focal seizures. The steady-state serum level of primidone rose when the patient received both drugs simultaneoulsy. The serum levels of the primidone metabolites, phenobarbital and phenylethylmalonamide, fell and the rate of metabolism of primidone decreased. The results are similar to those observed when isoniazid is adminstered with diphenylhydantoin.

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Year:  1975        PMID： 812007     DOI： 10.1212/wnl.25.12.1179

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  10 in total

1.  Inhibition of cytochrome P450 (CYP450) isoforms by isoniazid: potent inhibition of CYP2C19 and CYP3A.

Authors:  Z Desta; N V Soukhova; D A Flockhart
Journal:  Antimicrob Agents Chemother       Date:  2001-02       Impact factor: 5.191

2.  Lowering of theophylline clearance by isoniazid in slow and rapid acetylators.

Authors:  B Santoso
Journal:  Br J Clin Pharmacol       Date:  1990-05       Impact factor: 4.335

Review 3.  Interactions with antiepileptic drugs.

Authors:  A Richens
Journal:  Drugs       Date:  1977-04       Impact factor: 9.546

Review 4.  Pharmacokinetic interactions with antiepileptic drugs.

Authors:  E Perucca
Journal:  Clin Pharmacokinet       Date:  1982 Jan-Feb       Impact factor: 6.447

Review 5.  Anticonvulsant drugs. An update.

Authors:  M J Eadie
Journal:  Drugs       Date:  1984-04       Impact factor: 9.546

6.  Pharmacokinetics of phenylethylmalonamide (PEMA) after oral and intravenous administration.

Authors:  F Pisani; A Richens
Journal:  Clin Pharmacokinet       Date:  1983 May-Jun       Impact factor: 6.447

7.  Phenytoin: an inhibitor and inducer of primidone metabolism in an epileptic patient.

Authors:  M G Porro; H J Kupferberg; R J Porter; W H Theodore; M E Newmark
Journal:  Br J Clin Pharmacol       Date:  1982-08       Impact factor: 4.335

Review 8.  Clinical pharmacokinetics of isoniazid.

Authors:  W W Weber; D W Hein
Journal:  Clin Pharmacokinet       Date:  1979 Nov-Dec       Impact factor: 6.447

Review 9.  Antiepileptic drugs. A review of clinically significant drug interactions.

Authors:  P N Patsalos; J S Duncan
Journal:  Drug Saf       Date:  1993-09       Impact factor: 5.606

Review 10.  Clinical pharmacokinetics of the antituberculosis drugs.

Authors:  M R Holdiness
Journal:  Clin Pharmacokinet       Date:  1984 Nov-Dec       Impact factor: 6.447
  10 in total

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