Literature DB >> 8119786

Oxygen free radicals and acute pancreatitis: fact or fiction?

T A Creagh1, A L Leahy, D J Bouchier-Hayes, W Tormey, M Leader, P J Broe.   

Abstract

The effect of oxygen free radical suppression was studied in the taurocholate model of acute pancreatitis in the rat using systemic allopurinol, superoxide dismutase (S.O.D.) and catalase. None of the treatments were beneficial which suggests that oxygen free radical suppression is unlikely to be clinically beneficial in acute pancreatitis.

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Year:  1993        PMID： 8119786     DOI： 10.1007/bf03022581

Source DB:  PubMed          Journal:  Ir J Med Sci        ISSN： 0021-1265            Impact factor:   1.568


  11 in total

Review 1.  Pathophysiology of free radical-mediated reperfusion injury.

Authors:  G B Bulkley
Journal:  J Vasc Surg       Date:  1987-03       Impact factor: 4.268

2.  Failure of antioxidant therapy (polyethylene glycol-conjugated catalase) in acute pancreatitis.

Authors:  K S Guice; K T Oldham; K J Johnson
Journal:  Am J Surg       Date:  1989-01       Impact factor: 2.565

3.  Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase.

Authors:  A Abuchowski; J R McCoy; N C Palczuk; T van Es; F F Davis
Journal:  J Biol Chem       Date:  1977-06-10       Impact factor: 5.157

4.  The pathogenesis of acute pancreatitis. The source and role of oxygen-derived free radicals in three different experimental models.

Authors:  H Sanfey; G B Bulkley; J L Cameron
Journal:  Ann Surg       Date:  1985-05       Impact factor: 12.969

5.  Free radical inhibition and serial chemiluminescence in evolving experimental pancreatitis.

Authors:  D B Gough; B Boyle; W P Joyce; C P Delaney; K F McGeeney; T F Gorey; J M Fitzpatrick
Journal:  Br J Surg       Date:  1990-11       Impact factor: 6.939

Review 6.  Oxygen-derived free radicals and acute pancreatitis: a review.

Authors:  H Sanfey; M G Sarr; G B Bulkley; J L Cameron
Journal:  Acta Physiol Scand Suppl       Date:  1986

7.  Preparation of a polyethylene glycol: superoxide dismutase adduct, and an examination of its blood circulation life and anti-inflammatory activity.

Authors:  P S Pyatak; A Abuchowski; F F Davis
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1980-07

8.  Superoxide dismutase and catalase: a possible role in established pancreatitis.

Authors:  K S Guice; D E Miller; K T Oldham; C M Townsend; J C Thompson
Journal:  Am J Surg       Date:  1986-01       Impact factor: 2.565

9.  Organ chemiluminescence: noninvasive assay for oxidative radical reactions.

Authors:  A Boveris; E Cadenas; R Reiter; M Filipkowski; Y Nakase; B Chance
Journal:  Proc Natl Acad Sci U S A       Date:  1980-01       Impact factor: 11.205

10.  Experimental gallstone pancreatitis. Pathogenesis and response to different treatment modalities.

Authors:  P J Broe; J L Cameron
Journal:  Ann Surg       Date:  1982-05       Impact factor: 12.969
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