Literature DB >> 8119402

Both neurotoxin II from venom of Naja naja oxiana and its endogenous analogue induce apoptosis in tumor cells.

B N Strizhkov1, D K Satpaev, A A Karelin.   

Abstract

Both neurotoxin II (NT II from venom of Naja naja oxiana) and 20-30 kDa proteins partially purified from pig brain (NTlm) cross-reacting with antibodies to NT II were cytotoxic for L929 and K562 tumor cells at concentrations of 10(-6)-10(-8) M. Modification of Cys residues significantly reduced cytotoxicity of NT II. Both NT2 and NTlm induced apoptosis in L929 and K562 cells.

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Year:  1994        PMID: 8119402     DOI: 10.1016/0014-5793(94)80165-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN: 0014-5793            Impact factor:   4.124


  5 in total

1.  Serum from rabbit orally administered cobra venom inhibits growth of implanted hepatocellular carcinoma cells in mice.

Authors:  Peng Sun; Xian-Da Ren; Hai-Wei Zhang; Xiao-Hong Li; Shao-Hui Cai; Kai-He Ye; Xiao-Kun Li
Journal:  World J Gastroenterol       Date:  2003-11       Impact factor: 5.742

2.  Naja Naja Oxiana Venom Fraction Selectively Induces ROS-Mediated Apoptosis in Human Colorectal Tumor Cells by Directly Targeting Mitochondria

Authors:  Amir Fakhri; Ramesh Omranipour; Sara Fakhri; Mohammadreza Mirshamsi; Fatemeh Zangeneh; Hossein Vatanpour; Jalal Pourahmad
Journal:  Asian Pac J Cancer Prev       Date:  2017-08-27

3.  Anticancer Activity a of Caspian Cobra (Naja naja oxiana) snake Venom in Human Cancer Cell Lines Via Induction of Apoptosis.

Authors:  Karim Ebrahim; Hossein Vatanpour; Abbas Zare; Farshad H Shirazi; Mryam Nakhjavani
Journal:  Iran J Pharm Res       Date:  2016       Impact factor: 1.696

4.  The myth of cobra venom cytotoxin: More than just direct cytolytic actions.

Authors:  Jia Jin Hiu; Michelle Khai Khun Yap
Journal:  Toxicon X       Date:  2022-04-04

5.  Antitumor effect of Bothrops jararaca venom.

Authors:  Reinaldo J da Silva; Márcia G da Silva; Lízia C Vilela; Denise Fecchio
Journal:  Mediators Inflamm       Date:  2002-04       Impact factor: 4.711

  5 in total

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