Literature DB >> 8119374

Effect of pyrimethamine resistance on sporogony in a Plasmodium berghei/Anopheles stephensi model.

C J Shinondo1, H N Lanners, R C Lowrie, M F Wiser.   

Abstract

A pyrimethamine-resistant line of Plasmodium berghei was derived by treating infected mice with high doses of pyrimethamine and selecting for recrudescence. This resistant line was compared with the parental pyrimethamine-sensitive line in order to ascertain whether drug resistance is associated with a biological advantage. Overall, the pyrimethamine-resistant line is quite similar to the sensitive line, except that it proceeds through sporogonic development more slowly than the pyrimethamine-sensitive parental line. However, under pyrimethamine pressure the sensitive line is unable to undergo the sporogonic cycle, whereas the resistant line is unaffected. These results indicate that the transmission of pyrimethamine resistance in this model is favored only under conditions of drug pressure.

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Year:  1994        PMID： 8119374     DOI： 10.1006/expr.1994.1019

Source DB:  PubMed          Journal:  Exp Parasitol        ISSN： 0014-4894            Impact factor:   2.011


  8 in total

1.  High prevalence of markers for sulfadoxine and pyrimethamine resistance in Plasmodium falciparum in the absence of drug pressure in the Ashanti region of Ghana.

Authors:  Florian Marks; Jennifer Evans; Christian G Meyer; Edmund N Browne; Christa Flessner; Vera von Kalckreuth; Teunis A Eggelte; Rolf D Horstmann; Jürgen May
Journal:  Antimicrob Agents Chemother       Date:  2005-03       Impact factor: 5.191

2.  Mutations in cytochrome b resulting in atovaquone resistance are associated with loss of fitness in Plasmodium falciparum.

Authors:  Jennifer M Peters; Nanhua Chen; Michelle Gatton; Michael Korsinczky; Elizabeth V Fowler; Sergio Manzetti; Allan Saul; Qin Cheng
Journal:  Antimicrob Agents Chemother       Date:  2002-08       Impact factor: 5.191

Review 3.  The interplay between drug resistance and fitness in malaria parasites.

Authors:  Philip J Rosenthal
Journal:  Mol Microbiol       Date:  2013-08-16       Impact factor: 3.501

4.  Comparative Prevalence of Plasmodium falciparum Resistance-Associated Genetic Polymorphisms in Parasites Infecting Humans and Mosquitoes in Uganda.

Authors:  Melissa D Conrad; Daniel Mota; Alex Musiime; Maxwell Kilama; John Rek; Moses Kamya; Grant Dorsey; Philip J Rosenthal
Journal:  Am J Trop Med Hyg       Date:  2017-10-10       Impact factor: 2.345

5.  Resistance of a rodent malaria parasite to a thymidylate synthase inhibitor induces an apoptotic parasite death and imposes a huge cost of fitness.

Authors:  Francis W Muregi; Isao Ohta; Uchijima Masato; Hideto Kino; Akira Ishih
Journal:  PLoS One       Date:  2011-06-16       Impact factor: 3.240

6.  Fitness cost of resistance for lumefantrine and piperaquine-resistant Plasmodium berghei in a mouse model.

Authors:  Winnie R Gimode; Daniel M Kiboi; Francis T Kimani; Hannah N Wamakima; Marion W Burugu; Francis W Muregi
Journal:  Malar J       Date:  2015-01-28       Impact factor: 2.979

7.  Glucose-mediated proliferation of a gut commensal bacterium promotes Plasmodium infection by increasing mosquito midgut pH.

Authors:  Mengfei Wang; Yanpeng An; Li Gao; Shengzhang Dong; Xiaofeng Zhou; Yuebiao Feng; Penghua Wang; George Dimopoulos; Huiru Tang; Jingwen Wang
Journal:  Cell Rep       Date:  2021-04-20       Impact factor: 9.423

8.  Chloroquine resistance before and after its withdrawal in Kenya.

Authors:  Leah Mwai; Edwin Ochong; Abdi Abdirahman; Steven M Kiara; Steve Ward; Gilbert Kokwaro; Philip Sasi; Kevin Marsh; Steffen Borrmann; Margaret Mackinnon; Alexis Nzila
Journal:  Malar J       Date:  2009-05-18       Impact factor: 2.979
  8 in total

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