Literature DB >> 8119317

Effect of pertussis toxin treatment on the putative adenosine A3 receptor-mediated hypotensive response in the rat.

A M Carruthers1, J R Fozard.   

Abstract

The effect of pertussis toxin pretreatment on the putative A3 receptor-mediated hypotensive response to N6-2-(4-aminophenyl)ethyladenosine (APNEA) has been investigated in the anaesthetised rat. Pertussis toxin pretreatment essentially abolished the bradycardia induced by the prototype A1 receptor agonist, N6-cyclopentyladenosine, whereas the fall in blood pressure induced by the selective A2A receptor agonist, CGS 21680 was enhanced. Pertussis toxin substantially reduced the hypotensive response to APNEA. In this respect, the mechanism of action resembles that of the cloned A3 receptor which when expressed in CHO cells couples negatively to adenylate cyclase by a pertussis toxin-sensitive mechanism. The data provide further evidence that adenosine A3 receptors mediate the hypotensive response to APNEA in the rat.

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Year:  1993        PMID： 8119317     DOI： 10.1016/0014-2999(93)90641-t

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

1.  A3-adenosine receptors: design of selective ligands and therapeutic prospects.

Authors:  Kenneth A Jacobson; Hea O Kim; Suhaib M Siddiqi; Mark E Olah; Gary L Stiles; Dag K J E von Lubitz
Journal:  Drugs Future       Date:  1995-07       Impact factor: 0.148

2.  The receptor mechanism mediating the contractile response to adenosine on lung parenchymal strips from actively sensitised, allergen-challenged Brown Norway rats.

Authors:  Cedric Wolber; John R Fozard
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2005-01-27       Impact factor: 3.000

3.  Failure of CGS15943A to block the hypotensive action of agonists acting at the adenosine A3 receptor.

Authors:  M Patel; M J Sheehan; P Strong
Journal:  Br J Pharmacol       Date:  1994-11       Impact factor: 8.739

4.  A role for mast cells in adenosine A3 receptor-mediated hypotension in the rat.

Authors:  J P Hannon; H J Pfannkuche; J R Fozard
Journal:  Br J Pharmacol       Date:  1995-07       Impact factor: 8.739

5.  A SURVEY OF NONXANTHINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS.

Authors:  Suhaib M Siddiqi; Xiao-Duo Ji; Neli Melman; Mark E Olah; Rahul Jain; Patricia Evans; Marc Glashofer; William L Padgett; Louis A Cohen; John W Daly; Gary L Stiles; Kenneth A Jacobson
Journal:  Nucleosides Nucleotides       Date:  1996

6.  Mast cell adenosine receptors function: a focus on the a3 adenosine receptor and inflammation.

Authors:  Noam Rudich; Katya Ravid; Ronit Sagi-Eisenberg
Journal:  Front Immunol       Date:  2012-06-04       Impact factor: 7.561
  6 in total

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