| Literature DB >> 8119293 |
T Collin1, P Lory, S Taviaux, C Courtieu, P Guilbault, P Berta, J Nargeot.
Abstract
A novel human-voltage-dependent-calcium-channel (VDCC) beta subunit was isolated from a 9-week-old human total-embryo cDNA library. Of the four genes encoding beta-subunit isoforms that have been identified in animal species, this isoform shares strong similarity with the rat and rabbit beta 3-related gene product and is referred to here as H beta 3 subunit. The H beta 3 isoform is the second beta subunit identified in human. Its open reading frame encodes a 482-amino-acid protein with a predicted molecular mass of 54.571 kDa. The H beta 3 mRNA is expressed mostly in brain, smooth muscle and ovary. The gene for the human H beta 3 was specifically localized on chromosome 12q13. The cloned H beta 3 subunit was further expressed in Xenopus oocytes to demonstrate its ability to modulate VDCC activity.Entities:
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Year: 1994 PMID： 8119293 DOI： 10.1111/j.1432-1033.1994.tb18621.x
Source DB: PubMed Journal: Eur J Biochem ISSN： 0014-2956