Further evidence that a mouse chromosome 4 locus influences cerebellar folial pattern.

The cerebellar folial pattern of mice displays marked variation among inbred strains. Previous studies of progeny of crosses of C57BL/6 mice with DBA/2J and BALB/cByJ mice indicated a multifactorial mode of inheritance in both cases. The cross with DBA/2J led to the mapping, to Chromosome 4, of a locus (Cfp-1) that influences the frequency of the intraculminate fissure. Here we report that Cfp-1 influences the frequency of the declival sulcus, and appears to influence the frequency of the intraculminate and precentral fissures, in F2 hybrid offspring from crosses of C57BL/6J and BALB/cByJ mice.