Literature DB >> 811772

Enzymatic inhibition of diphosphonate: a proposed mechanism of tissue uptake.

A M Zimmer, A T Isitman, R A Holmes.   

Abstract

Enzymes have been proposed as tissue receptors that bine 99mTc-stannous diphosphonate and its analogs. Incubation of diphosphonate with several enzymes demonstrated inhibition of acid and alkaline phosphatase activity but showed no effect on glutamic oxalacetic transaminase and lactate dehydrogenase activity. Complete reversal of the diphosphonate-induced inhibition of alkaline phosphatase activity occurred when calcium ion was added to the reaction. The specificity of calcium to induce reversal was dispelled when magnesium ion gave identical results. Diphosphonate-induced inhibition of acid phosphatase, however, was not reversed by calcium or magnesium.

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Year:  1975        PMID： 811772

Source DB:  PubMed          Journal:  J Nucl Med        ISSN： 0161-5505            Impact factor:   10.057


  15 in total

1.  Accumulation of 99m Tc-Sn-pyrophosphate in pleural effusions.

Authors:  C Aprile; G Bernardo; M Carena; A Favino; G R Cuna; M R Strada; S Mascherpa
Journal:  Eur J Nucl Med       Date:  1978

2.  Sites and mechanisms of localization of technetium-99m phosphorus radiopharmaceuticals in acute myocardial infarcts and other tissues.

Authors:  L M Buja; A J Tofe; P V Kulkarni; A Mukherjee; R W Parkey; M D Francis; F J Bonte; J T Willerson
Journal:  J Clin Invest       Date:  1977-09       Impact factor: 14.808

3.  Hepatic metastasis arising from diverse primary pathologies diagnosed on 99mTc-Methylene diphosphonate bone scan.

Authors:  M L Narayan; N Ravishwar; A Y Lakshmi; N Rukmangadha; T C Kalawat; R G Manthri
Journal:  Indian J Nucl Med       Date:  2015 Apr-Jun

4.  Ectopic accumulation of 99mTc-HMDP in primary lung cancer in comparison with CT findings.

Authors:  S Yoshida; M Fukumoto; N Yoshimura; K Oobayashi; Y Takada
Journal:  Ann Nucl Med       Date:  1996-08       Impact factor: 2.668

5.  Localization of 99mTc-diphosphonate in a surgical scar: a speculative case report and a review of the literature.

Authors:  J R Prince
Journal:  Eur J Nucl Med       Date:  1979-02-01

6.  In vitro interaction between 99Tcm-labeled pyrophosphate, 32P-labeled pyrophosphate and rat tissues.

Authors:  M Rohlin; A Larsson; L Hammarström
Journal:  Eur J Nucl Med       Date:  1978

7.  Accumulation of technetium-99m MDP in pseudomyxoma peritonei.

Authors:  T Kida; F Tsuda; Y Fujita; S Munakata; M Sasaki
Journal:  Ann Nucl Med       Date:  1990-11       Impact factor: 2.668

8.  Three-phase bone scintigraphy of hydroxyapatite ocular implants.

Authors:  T Leitha; A Staudenherz; U Scholz
Journal:  Eur J Nucl Med       Date:  1995-04

9.  Tc-99m-HMDP bone uptake quantification and plasma osteocalcin levels in hemodialysis patients--a preliminary study.

Authors:  U Karayalcin; B Karayalcin; G Yakupoglu; A Yildiz; M Erkilic
Journal:  Ann Nucl Med       Date:  1992-02       Impact factor: 2.668

10.  99mTc-MDP extraction in relation to 81mKr perfusion following a partial osteotomy in the dog tibia.

Authors:  R A Khan
Journal:  Experientia       Date:  1980-10-15
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