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Literature DB >> 8117428

Non-pharmacological treatment of sleep and wake disturbances in aging and Alzheimer's disease: chronobiological perspectives.

E J van Someren¹, M Mirmiran, D F Swaab.

Abstract

Numerous studies indicate a deterioration of nighttime sleep and daytime cognitive performance in elderly people and Alzheimer patients. As a result of the increasing number of elderly people and Alzheimer patients in the western society, attention for these problems has grown. However, so far, the major research effort has been concentrating on the development of pharmacological therapies for an isolated age-related problem. In the present review it is argued that several age-related problems with sleep and wakefulness may reflect a dampening of circadian rhythm amplitudes. Non-pharmacological manipulation of circadian rhythms by means of various external stimuli appears to be effective in improving sleep and cognitive functioning in elderly people and Alzheimer patients.

Entities: Disease Species

Mesh：

Year: 1993 PMID： 8117428 DOI： 10.1016/0166-4328(93)90140-l

Source DB: PubMed Journal: Behav Brain Res ISSN： 0166-4328 Impact factor: 3.332

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Cited

17 in total

1. Brief morning light treatment for sleep/wake disturbances in older memory-impaired individuals and their caregivers.

Authors: Leah Friedman; Adam P Spira; Beatriz Hernandez; Christina Mather; Javaid Sheikh; Sonia Ancoli-Israel; Jerome A Yesavage; Jamie M Zeitzer
Journal: Sleep Med Date: 2012-03-10 Impact factor: 3.492

2. Responsiveness of the aging circadian clock to light.

Authors: S Benloucif; K Green; M L'Hermite-Balériaux; S Weintraub; L F Wolfe; P C Zee
Journal: Neurobiol Aging Date: 2005-11-23 Impact factor: 4.673

3. The effects of evening light exposure on the sleep of elderly women expressing sleep complaints.

Authors: K M Cooke; M A Kreydatus; A Atherton; E B Thoman
Journal: J Behav Med Date: 1998-02

4. Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms.

Authors: D J Dijk; J F Duffy; E Riel; T L Shanahan; C A Czeisler
Journal: J Physiol Date: 1999-04-15 Impact factor: 5.182

10. Differences in circadian rhythmicity in CLOCK 3111T/C genetic variants in moderate obese women as assessed by thermometry, actimetry and body position.

Authors: C Bandín; A Martinez-Nicolas; J M Ordovás; J A Ros Lucas; P Castell; T Silvente; J A Madrid; M Garaulet
Journal: Int J Obes (Lond) Date: 2012-11-20 Impact factor: 5.095

Non-pharmacological treatment of sleep and wake disturbances in aging and Alzheimer's disease: chronobiological perspectives.

1. Brief morning light treatment for sleep/wake disturbances in older memory-impaired individuals and their caregivers.

2. Responsiveness of the aging circadian clock to light.

3. The effects of evening light exposure on the sleep of elderly women expressing sleep complaints.

4. Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms.

5. Age-related disruptions of circadian rhythm and memory in the senescence-accelerated mouse (SAMP8).

Review 6. Sleep disturbances in patients with Alzheimer's disease: epidemiology, pathophysiology and treatment.

7. Scheduled bright light for treatment of insomnia in older adults.

8. Circadian rhythmicity as a predictor of weight-loss effectiveness.

9. Evening physical activity alters wrist temperature circadian rhythmicity.

10. Differences in circadian rhythmicity in CLOCK 3111T/C genetic variants in moderate obese women as assessed by thermometry, actimetry and body position.