Literature DB >> 8116227

Gastric adenocarcinoma with differentiation to sarcomatous components associated with monoclonal Epstein-Barr virus infection and LMP-1 expression.

Y Kida1, K Miyauchi, Y Takano.   

Abstract

A case of gastric adenocarcinoma with sarcomatous differentiation in a 65-year-old male was investigated for possible association with the Epstein-Barr virus (EBV). The presence of EBV-DNA could be proven by the polymerase chain reaction (PCR), and EBERs signals were detected in tumour nuclei, strongly in sarcomatous areas and weakly elsewhere. Monoclonal EBV infection was evident in terms of a single band of lymphocyte determined membrane antigen demonstrated by the PCR method. Latent membrane protein 1 was strongly positive in cells of sarcomatous components but very weakly positive in carcinoma components. EBV-determined nuclear antigen-2 was absent in both. This case of adenocarcinoma suggests that EBV plays an important role in tumorigenesis, contributing in particular to sarcomatous differentiation.

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Year:  1993        PMID： 8116227     DOI： 10.1007/bf01607151

Source DB:  PubMed          Journal:  Virchows Arch A Pathol Anat Histopathol        ISSN： 0174-7398


  26 in total

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Authors:  A P Burke; T S Yen; K M Shekitka; L H Sobin
Journal:  Mod Pathol       Date:  1990-05       Impact factor: 7.842

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Journal:  Nature       Date:  1989-08-03       Impact factor: 49.962

7.  Epstein-Barr virus in benign lymph node biopsies from individuals infected with the human immunodeficiency virus is associated with concurrent or subsequent development of non-Hodgkin's lymphoma.

Authors:  D Shibata; L M Weiss; B N Nathwani; R K Brynes; A M Levine
Journal:  Blood       Date:  1991-04-01       Impact factor: 22.113

8.  Association of Epstein-Barr virus with undifferentiated gastric carcinomas with intense lymphoid infiltration. Lymphoepithelioma-like carcinoma.

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Journal:  Am J Pathol       Date:  1991-09       Impact factor: 4.307

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Journal:  Am J Pathol       Date:  1991-08       Impact factor: 4.307

10.  Polypoid tumor of the esophagus.

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Journal:  Hum Pathol       Date:  1987-07       Impact factor: 3.466
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  6 in total

1.  Epstein-Barr virus LMP1 modulates the malignant potential of gastric carcinoma cells involving apoptosis.

Authors:  L F Sheu; A Chen; Y H Wei; K C Ho; J Y Cheng; C L Meng; W H Lee
Journal:  Am J Pathol       Date:  1998-01       Impact factor: 4.307

2.  Deletion of Epstein-Barr virus latent membrane protein 1 gene in Japanese and Brazilian gastric carcinomas, metastatic lesions, and reactive lymphocytes.

Authors:  K Hayashi; W G Chen; Y Y Chen; I Murakami; H L Chen; N Ohara; S Nose; K Hamaya; S Matsui; M M Bacchi; C E Bacchi; K L Chang; L M Weiss
Journal:  Am J Pathol       Date:  1998-01       Impact factor: 4.307

3.  Epstein-Barr virus-specific methylation of human genes in gastric cancer cells.

Authors:  Julie L Ryan; Richard J Jones; Shannon C Kenney; Ashley G Rivenbark; Weihua Tang; Elizabeth Rw Knight; William B Coleman; Margaret L Gulley
Journal:  Infect Agent Cancer       Date:  2010-12-31       Impact factor: 2.965

Review 4.  Epstein-barr virus in gastric carcinoma.

Authors:  Jun Nishikawa; Hironori Yoshiyama; Hisashi Iizasa; Yuichi Kanehiro; Munetaka Nakamura; Junichi Nishimura; Mari Saito; Takeshi Okamoto; Kouhei Sakai; Yutaka Suehiro; Takahiro Yamasaki; Atsunori Oga; Hideo Yanai; Isao Sakaida
Journal:  Cancers (Basel)       Date:  2014-11-07       Impact factor: 6.639

Review 5.  The Role of Epigenetic Regulation in Epstein-Barr Virus-Associated Gastric Cancer.

Authors:  Jun Nishikawa; Hisashi Iizasa; Hironori Yoshiyama; Munetaka Nakamura; Mari Saito; Sho Sasaki; Kanami Shimokuri; Masashi Yanagihara; Kouhei Sakai; Yutaka Suehiro; Takahiro Yamasaki; Isao Sakaida
Journal:  Int J Mol Sci       Date:  2017-07-25       Impact factor: 5.923

6.  Epstein-barr virus infected gastric adenocarcinoma expresses latent and lytic viral transcripts and has a distinct human gene expression profile.

Authors:  Weihua Tang; Douglas R Morgan; Michael O Meyers; Ricardo L Dominguez; Enrique Martinez; Kennichi Kakudo; Pei Fen Kuan; Natalie Banet; Hind Muallem; Kimberly Woodward; Olga Speck; Margaret L Gulley
Journal:  Infect Agent Cancer       Date:  2012-08-28       Impact factor: 2.965
  6 in total

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