The role of reproductive hormones in vascular disease and hypertension.

Review of pertinent research demonstrates a link between sex steroids and vascular disease. Evidence for this association includes: beneficial effect of estrogens on the blood lipids (elevation of high-density lipoproteins and lowering of low-density lipoproteins), adverse effect of high-dose synthetic estrogens on coagulation, vasodilating action of progesterone, and adverse effect of androgens and androgen-derived progestagens on lipoproteins. Natural steroids appear to differ in their impact from synthetic compounds; endogenous hormones from exogenous and parenterally administered preparations. Furthermore, steroids have different effects at different concentrations, doses, and ratios. Their actions also vary according to age, sex, pregnant or nonpregnant state, body weight, smoking, and other risk factors. In this article, the following areas will be considered in relation to the impact of sex steroids on cardiovascular phenomena and hypertension: menstrual cycle and its disturbances; amenorrhea and hyperandrogenism; pregnancy with its hyperdynamic state and a tendency to gestational hypertension; oral-contraception-induced, dose-related thromboembolic phenomena; menopause and estrogen deficiency states with increased incidence of atherogenesis; estrogen replacement therapy with its decrease in cardiovascular morbidity; other hormonal therapies which induce hypoestrogenism with its consequences. The evidence is emerging that hormonal modifications may be useful in the prevention of cardiovascular morbidity.