Literature DB >> 811569

Modulation of the formation and release of bovine SRS-A in vitro by several anti-anaphylactic drugs.

J F Burka, P Eyre.   

Abstract

Slow-reacting substance of anaphylaxis (SRS-A) is released immunologically from bovine lung in vitro. Various drugs known to protect calves and other animals during anaphylaxis were tested to investigate their modulation of the formation and release of SRS-A. The anti-inflammatory drugs, meclofenamate and aspirin, potentiated SRS-A release. Chlorphenesin and diethylcarbamazine citrate at high concentrations both inhibited SRS-A release. Two new anti-anaphylactic drugs, PR-D-92-EA and M&B 22,948, were particularly effective in inhibiting SRS-A release at low concentrations. The possible modes of actions of these drugs are discussed.

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Year:  1975        PMID： 811569     DOI： 10.1159/000231461

Source DB:  PubMed          Journal:  Int Arch Allergy Appl Immunol        ISSN： 0020-5915


  11 in total

Review 1.  The Schultz-Dale reaction: a review.

Authors:  N Chand; P Eyre
Journal:  Agents Actions       Date:  1978-04

2.  The effect of Ro 21-7634 on the antigen-induced production of bronchoconstrictive arachidonic acid metabolites in the guinea pig lung.

Authors:  A F Welton; H J Crowley; G Folco; T Viganó
Journal:  Agents Actions       Date:  1982-10

Review 3.  Auto-modulation of release of pharmacological mediators of immediate (type I) hypersensitivity. A review.

Authors:  M C Holroyde; J F Burka; P Eyre
Journal:  Agents Actions       Date:  1977-10

4.  The pharmacology of anaphylaxis in the chicken intestine.

Authors:  N Chand; P Eyre
Journal:  Br J Pharmacol       Date:  1976-07       Impact factor: 8.739

5.  Effect of inhibition of arachidonic acid metabolism on anaphylaxis of guinea pig lung strips.

Authors:  S S Yen; W Kreutner
Journal:  Agents Actions       Date:  1980-06

6.  Effects of modulators of arachidonic acid metabolism on the synthesis and release of slow-reacting substance of anaphylaxis.

Authors:  J F Burka; R J Flower
Journal:  Br J Pharmacol       Date:  1979-01       Impact factor: 8.739

Review 7.  Nonsteroidal anti-inflammatory drugs: a review. New applications in hypersensitivity reactions of cattle and horses.

Authors:  N Chand; P Eyre
Journal:  Can J Comp Med       Date:  1977-07

8.  Immunological release of histamine and slow-reacting substance in domestic fowl.

Authors:  N Chand; P Eyre
Journal:  Can J Comp Med       Date:  1978-10

9.  Pharmacological modulation of responses of guinea-pig airways contracted with antigen and calcium ionophore A23187.

Authors:  J F Burka
Journal:  Br J Pharmacol       Date:  1985-06       Impact factor: 8.739

10.  Enhancement of acute allergic inflammation by indomethacin is reversed by prostaglandin E2: apparent correlation with in vivo modulation of mediator release.

Authors:  J Raud; S E Dahlén; A Sydbom; L Lindbom; P Hedqvist
Journal:  Proc Natl Acad Sci U S A       Date:  1988-04       Impact factor: 11.205
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