PURPOSE: To prospectively study the cerebrospinal fluid volume-total intracranial volume ratio (CSF/ICV) in human immunodeficiency virus (HIV)-infected patients at various stages of disease. MATERIALS AND METHODS: A total of 258 volume measurements were obtained with use of a 1.5-T magnetic resonance (MR) imager and the cluster localized automated spherical segmentation technique (which reduces two-dimensional pixel data from dual spin-echo MR images to a one-dimensional histogram) in 69 control subjects and 189 HIV-infected patients. RESULTS: The CSF/ICV was statistically significantly increased in patients with late-stage (Centers for Disease Control and Prevention group IV) acquired immunodeficiency syndrome (AIDS) (0.16 +/- 0.05 [standard deviation]) compared with seronegative control subjects (0.12 +/- 0.03) and patients without symptoms (0.13 +/- 0.03). CONCLUSION: No substantial change in CSF/ICV occurs until development of late-stage AIDS.
PURPOSE: To prospectively study the cerebrospinal fluid volume-total intracranial volume ratio (CSF/ICV) in human immunodeficiency virus (HIV)-infectedpatients at various stages of disease. MATERIALS AND METHODS: A total of 258 volume measurements were obtained with use of a 1.5-T magnetic resonance (MR) imager and the cluster localized automated spherical segmentation technique (which reduces two-dimensional pixel data from dual spin-echo MR images to a one-dimensional histogram) in 69 control subjects and 189 HIV-infectedpatients. RESULTS: The CSF/ICV was statistically significantly increased in patients with late-stage (Centers for Disease Control and Prevention group IV) acquired immunodeficiency syndrome (AIDS) (0.16 +/- 0.05 [standard deviation]) compared with seronegative control subjects (0.12 +/- 0.03) and patients without symptoms (0.13 +/- 0.03). CONCLUSION: No substantial change in CSF/ICV occurs until development of late-stage AIDS.
Authors: I D Wilkinson; S Lunn; K A Miszkiel; R F Miller; M N Paley; I Williams; R J Chinn; M A Hall-Craggs; S P Newman; B E Kendall; M J Harrison Journal: J Neurol Neurosurg Psychiatry Date: 1997-10 Impact factor: 10.154
Authors: I P Everall; W K Chong; I D Wilkinson; M N Paley; R J Chinn; M A Hall-Craggs; F Scaravilli; P L Lantos; P J Luthert; M J Harrison Journal: J Neurol Neurosurg Psychiatry Date: 1997-01 Impact factor: 10.154
Authors: Sohil H Patel; Dennis L Kolson; Guila Glosser; Isabel Matozzo; Yulin Ge; James S Babb; Lois J Mannon; Robert I Grossman Journal: AJNR Am J Neuroradiol Date: 2002-04 Impact factor: 3.825
Authors: R F Miller; S B Lucas; M A Hall-Craggs; N S Brink; F Scaravilli; R J Chinn; B E Kendall; I G Williams; M J Harrison Journal: J Neurol Neurosurg Psychiatry Date: 1997-04 Impact factor: 10.154
Authors: M J Harrison; S P Newman; M A Hall-Craggs; C J Fowler; R Miller; B E Kendall; M Paley; I Wilkinson; B Sweeney; S Lunn; S Carter; I Williams Journal: J Neurol Neurosurg Psychiatry Date: 1998-09 Impact factor: 10.154