Literature DB >> 8114954

Neuropeptide Y potentiates via Y2-receptors the inhibitory effect of noradrenaline in rat locus coeruleus neurones.

P Illes1, E P Finta, K Nieber.   

Abstract

Intracellular recordings were carried out in a pontine slice preparation of the rat brain containing the locus coeruleus (LC). Pressure application of noradrenaline with various pulse durations inhibited the spontaneous frequency of action potentials and hyperpolarized the membrane. Neuropeptide Y (NPY), its C-terminal fragment NPY (16-36) and peptide YY (PYY), at a concentration of 0.1 mumol/l all, potentiated the effect of noradrenaline, while [Leu31, Pro34]NPY (0.1 mumol/l) was inactive. These results are compatible with the presence of Y2-type NPY-receptors at the cell somata of LC neurones.

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Year:  1993        PMID： 8114954     DOI： 10.1007/bf00173217

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  18 in total

1.  EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS.

Authors:  A DAHLSTROEM; K FUXE
Journal:  Acta Physiol Scand Suppl       Date:  1964

2.  Presynaptic inhibition by neuropeptide Y in rat hippocampal slice in vitro is mediated by a Y2 receptor.

Authors:  W F Colmers; G J Klapstein; A Fournier; S St-Pierre; K A Treherne
Journal:  Br J Pharmacol       Date:  1991-01       Impact factor: 8.739

Review 3.  Receptor interactions at noradrenergic neurones.

Authors:  P Illes; H D Weber; J Neuburger; B Bucher; J T Regenold; W Nörenberg
Journal:  Ann N Y Acad Sci       Date:  1990       Impact factor: 5.691

Review 4.  Receptors for neuropeptide Y: multiple subtypes and multiple second messengers.

Authors:  M C Michel
Journal:  Trends Pharmacol Sci       Date:  1991-10       Impact factor: 14.819

Review 5.  Common alpha 2- and opiate effector mechanisms in the locus coeruleus: intracellular studies in brain slices.

Authors:  G K Aghajanian; Y Y Wang
Journal:  Neuropharmacology       Date:  1987-07       Impact factor: 5.250

6.  Characterization of alpha 2-adrenoceptors which increase potassium conductance in rat locus coeruleus neurones.

Authors:  J T Williams; G Henderson; R A North
Journal:  Neuroscience       Date:  1985-01       Impact factor: 3.590

7.  Neuropeptide Y--a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide.

Authors:  K Tatemoto; M Carlquist; V Mutt
Journal:  Nature       Date:  1982-04-15       Impact factor: 49.962

8.  Neuropeptide Y selectively inhibits slow synaptic potentials in rat dorsal raphe nucleus in vitro by a presynaptic action.

Authors:  S B Kombian; W F Colmers
Journal:  J Neurosci       Date:  1992-03       Impact factor: 6.167

9.  Noradrenaline-mediated synaptic inhibition in rat locus coeruleus neurones.

Authors:  T M Egan; G Henderson; R A North; J T Williams
Journal:  J Physiol       Date:  1983-12       Impact factor: 5.182

10.  Opiate-receptor interactions on single locus coeruleus neurones.

Authors:  J T Williams; R A North
Journal:  Mol Pharmacol       Date:  1984-11       Impact factor: 4.436
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  11 in total

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Authors:  Valerie G Olson; Hannah R Rockett; Rebecca K Reh; Van A Redila; Phuong M Tran; Heli A Venkov; Mia C Defino; Chris Hague; Elaine R Peskind; Patricia Szot; Murray A Raskind
Journal:  Biol Psychiatry       Date:  2011-01-20       Impact factor: 13.382

2.  Inflammatory Factors Mediate Vulnerability to a Social Stress-Induced Depressive-like Phenotype in Passive Coping Rats.

Authors:  Susan K Wood; Christopher S Wood; Calliandra M Lombard; Catherine S Lee; Xiao-Yan Zhang; Julie E Finnell; Rita J Valentino
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Review 3.  Corticotropin-releasing factor (CRF) and neuropeptide Y (NPY): effects on inhibitory transmission in central amygdala, and anxiety- & alcohol-related behaviors.

Authors:  Nicholas W Gilpin
Journal:  Alcohol       Date:  2012-05-04       Impact factor: 2.405

4.  Hypoxic changes in rat locus coeruleus neurons in vitro.

Authors:  K Nieber; J Sevcik; P Illes
Journal:  J Physiol       Date:  1995-07-01       Impact factor: 5.182

5.  The psychobiology of resilience and vulnerability to anxiety disorders: implications for prevention and treatment.

Authors:  Dennis S Charney
Journal:  Dialogues Clin Neurosci       Date:  2003-09       Impact factor: 5.986

6.  Targeting the Neuropeptide Y System in Stress-related Psychiatric Disorders.

Authors:  Nicole M Enman; Esther L Sabban; Paul McGonigle; Elisabeth J Van Bockstaele
Journal:  Neurobiol Stress       Date:  2015-01-01

7.  Resilience to the effects of social stress: evidence from clinical and preclinical studies on the role of coping strategies.

Authors:  Susan K Wood; Seema Bhatnagar
Journal:  Neurobiol Stress       Date:  2015-01-01

8.  Ultrastructural Correlates of Enhanced Norepinephrine and Neuropeptide Y Cotransmission in the Spontaneously Hypertensive Rat Brain.

Authors:  Ioannis Kourtesis; Sergey Kasparov; Paul Verkade; Anja G Teschemacher
Journal:  ASN Neuro       Date:  2015-10-29       Impact factor: 4.146

9.  Individual differences in the neurobiology of social stress: implications for depression-cardiovascular disease comorbidity.

Authors:  Susan K Wood
Journal:  Curr Neuropharmacol       Date:  2014-03       Impact factor: 7.363

Review 10.  Cardiac autonomic imbalance by social stress in rodents: understanding putative biomarkers.

Authors:  Susan K Wood
Journal:  Front Psychol       Date:  2014-08-26
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