Literature DB >> 8114609

Methylphenidate decreases regional cerebral blood flow in normal human subjects.

G J Wang1, N D Volkow, J S Fowler, R Ferrieri, D J Schlyer, D Alexoff, N Pappas, J Lieberman, P King, D Warner.   

Abstract

To assess the effects of methylphenidate (MP) on cerebral blood flow (CBF), 5 healthy males were studied using 15O-water and positron emission tomography before and after MP (0.5 mg/kg iv). MP significantly decreased whole brain CBF at 5-10 minutes (25 +/- 11%) and at 30 minutes (20 +/- 10%) after its administration. Decrements in CBF were homogeneous throughout the brain (regional decrements 23-30%) and probably reflect the vasoactive properties of MP. The vasoactive properties of MP should be considered when prescribing this drug chronically and/or when giving it to subjects with cerebrovascular compromise.

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Year:  1994        PMID： 8114609     DOI： 10.1016/0024-3205(94)00873-6

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  7 in total

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Authors:  Nora D Volkow; Gene-Jack Wang; Frank Telang; Joanna S Fowler; David Alexoff; Jean Logan; Millard Jayne; Christopher Wong; Dardo Tomasi
Journal:  Proc Natl Acad Sci U S A       Date:  2014-07-14       Impact factor: 11.205

2.  Methylphenidate modulates sustained attention and cortical activation in survivors of traumatic brain injury: a perfusion fMRI study.

Authors:  Junghoon Kim; John Whyte; Sunil Patel; Eduardo Europa; Jiongjiong Wang; H Branch Coslett; John A Detre
Journal:  Psychopharmacology (Berl)       Date:  2011-12-28       Impact factor: 4.530

3.  Assessment of endogenous dopamine release by methylphenidate challenge using iodine-123 iodobenzamide single-photon emission tomography.

Authors:  J Booij; P Korn; D H Linszen; E A van Royen
Journal:  Eur J Nucl Med       Date:  1997-06

4.  Methylphenidate-induced activation of the anterior cingulate but not the striatum: a [15O]H2O PET study in healthy volunteers.

Authors:  Joanna I Udo de Haes; R Paul Maguire; Piet L Jager; Anne M J Paans; Johan A den Boer
Journal:  Hum Brain Mapp       Date:  2007-07       Impact factor: 5.038

5.  On the nature of extraversion: variation in conditioned contextual activation of dopamine-facilitated affective, cognitive, and motor processes.

Authors:  Richard A Depue; Yu Fu
Journal:  Front Hum Neurosci       Date:  2013-06-13       Impact factor: 3.169

6.  Cocaine attenuates blood flow but not neuronal responses to stimulation while preserving neurovascular coupling for resting brain activity.

Authors:  W Chen; P Liu; N D Volkow; Y Pan; C Du
Journal:  Mol Psychiatry       Date:  2015-12-15       Impact factor: 15.992

7.  High reward expectancy during methylphenidate depresses the dopaminergic response to gain and loss.

Authors:  E A Evers; P Stiers; J G Ramaekers
Journal:  Soc Cogn Affect Neurosci       Date:  2017-02-01       Impact factor: 3.436
  7 in total

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