Literature DB >> 811391

[Trypanocidal activity of some ellipticine derivatives against Trypanosoma cruzi cultured in vitro].

J Bénard, N Dat-Xuong, G Riou.   

Abstract

Some ellipticine derivatives showing antitumoral behaviour exhibit a trypanocide activity against in vitro cultures of T. cruzi. 9-Methoxy-6-methyl-ellipticine is the most active compound of this series: its lethal effect is comparable with that of ethidium bromide.

Entities:  

Mesh:

Substances:

Year:  1975        PMID: 811391

Source DB:  PubMed          Journal:  C R Acad Hebd Seances Acad Sci D


  2 in total

1.  Inhibition of the reactions catalysed by a type I topoisomerase and catenating enzyme of Trypanosoma cruzi by DNA-intercalating drugs. Preferential inhibition of the catenating reaction.

Authors:  S Douc-Rasy; A Kayser; G F Riou
Journal:  EMBO J       Date:  1984-01       Impact factor: 11.598

2.  Alkaloids induce programmed cell death in bloodstream forms of trypanosomes (Trypanosoma b. brucei).

Authors:  Vera Rosenkranz; Michael Wink
Journal:  Molecules       Date:  2008-10-03       Impact factor: 4.411

  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.