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Literature DB >> 8113524

Treating periodontal diseases by blocking tissue-destructive enzymes.

L M Golub¹, M Wolff, S Roberts, H M Lee, M Leung, G S Payonk.

Abstract

A new therapeutic approach involves the discovery by the "Stony Brook group," that tetracyclines, but not other antibiotics, can inhibit host-derived collagen-destructive enzymes. This newly discovered property of tetracyclines is unrelated to the antimicrobial activity of these drugs. Examples support the hypothesis that this unexpected property of tetracyclines provides a new approach to treating periodontal diseases as well as a variety of medical disorders.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1994 PMID： 8113524 DOI： 10.14219/jada.archive.1994.0261

Source DB: PubMed Journal: J Am Dent Assoc ISSN： 0002-8177 Impact factor: 3.634

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Cited

12 in total

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Authors: D Grenier; M P Huot; D Mayrand
Journal: Antimicrob Agents Chemother Date: 2000-03 Impact factor: 5.191

2. Inhibition of trypsin-like cysteine proteinases (gingipains) from Porphyromonas gingivalis by tetracycline and its analogues.

Authors: T Imamura; K Matsushita; J Travis; J Potempa
Journal: Antimicrob Agents Chemother Date: 2001-10 Impact factor: 5.191

3. Activation of a 66-kilodalton human endothelial cell matrix metalloprotease by Streptococcus pyogenes extracellular cysteine protease.

Authors: E H Burns; A M Marciel; J M Musser
Journal: Infect Immun Date: 1996-11 Impact factor: 3.441

Review 4. Oral fluid-based biomarkers of alveolar bone loss in periodontitis.

Authors: Janet S Kinney; Christoph A Ramseier; William V Giannobile
Journal: Ann N Y Acad Sci Date: 2007-03 Impact factor: 5.691

5. The effect of laser irradiation and doxycycline application on the production of matrix metalloproteinase-8 and collagen I from cultured human periodontal ligament cells.

Authors: Alireza Dehdashtizadeh; Nasim Esnaashari; Shirin Zahra Farhad; Fatemeh Ejeian; Shaharam Amini
Journal: Dent Res J (Isfahan) Date: 2020-05-23

6. Triclosan blocks MMP-13 expression in hormone-stimulated osteoblasts.

Authors: Virginia Monsul Barnes; Tao Xu; Emi Shimizu; Teruyo Nakatani; Steven Jefcoat; Anatoliy Vasilov; Ling Qin; Nicola C Partridge
Journal: J Periodontol Date: 2013-01-31 Impact factor: 6.993

7. Multilevel analysis of clinical parameters in chronic periodontitis after root planing/scaling, surgery, and systemic and local antibiotics: 2-year results.

Authors: Ibrahimu Mdala; Anne D Haffajee; Sigmund S Socransky; Birgitte Freiesleben de Blasio; Magne Thoresen; Ingar Olsen; J Max Goodson
Journal: J Oral Microbiol Date: 2012-04-24 Impact factor: 5.474