Literature DB >> 8113146

Cisplatin blocks mechano-electric transducer current in chick cochlear hair cells.

T Kimitsuki1, T Nakagawa, K Hisashi, S Komune, S Komiyama.   

Abstract

The effects of cisplatin (cis-dichlorodiammine platinum II, CDDP) on the mechano-electrical transduction (MET) current were investigated with a whole-cell patch-electrode voltage clamp technique in dissociated cochlear hair cells of chicks. CDDP blocked the MET channel in a dose- and voltage-dependent manner. At -50 mV, CDDP blocked the MET channel with a Hill coefficient of approximately 2 and a dissociation constant (KD) of 1.5 x 10(-3) M. The kinetics of CDDP blockade consist of a voltage-independent and a voltage-dependent component.

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Year:  1993        PMID： 8113146     DOI： 10.1016/0378-5955(93)90021-r

Source DB:  PubMed          Journal:  Hear Res        ISSN： 0378-5955            Impact factor:   3.208


  10 in total

1.  Probing the pore of the auditory hair cell mechanotransducer channel in turtle.

Authors:  H E Farris; C L LeBlanc; J Goswami; A J Ricci
Journal:  J Physiol       Date:  2004-06-04       Impact factor: 5.182

Review 2.  Aminoglycoside- and Cisplatin-Induced Ototoxicity: Mechanisms and Otoprotective Strategies.

Authors:  Corné J Kros; Peter S Steyger
Journal:  Cold Spring Harb Perspect Med       Date:  2019-11-01       Impact factor: 6.915

3.  Cisplatin ototoxicity in rat cochlear organotypic cultures.

Authors:  Dalian Ding; Jingchun He; Brian L Allman; Dongzhen Yu; Haiyan Jiang; Gail M Seigel; Richard J Salvi
Journal:  Hear Res       Date:  2011-08-12       Impact factor: 3.208

4.  Functional mechanotransduction is required for cisplatin-induced hair cell death in the zebrafish lateral line.

Authors:  Andrew J Thomas; Dale W Hailey; Tamara M Stawicki; Patricia Wu; Allison B Coffin; Edwin W Rubel; David W Raible; Julian A Simon; Henry C Ou
Journal:  J Neurosci       Date:  2013-03-06       Impact factor: 6.167

Review 5.  Reactive oxygen species, apoptosis, and mitochondrial dysfunction in hearing loss.

Authors:  Teru Kamogashira; Chisato Fujimoto; Tatsuya Yamasoba
Journal:  Biomed Res Int       Date:  2015-03-22       Impact factor: 3.411

Review 6.  Mechanisms of Cisplatin-Induced Ototoxicity and Otoprotection.

Authors:  Sandeep Sheth; Debashree Mukherjea; Leonard P Rybak; Vickram Ramkumar
Journal:  Front Cell Neurosci       Date:  2017-10-27       Impact factor: 5.505

7.  ORC-13661 protects sensory hair cells from aminoglycoside and cisplatin ototoxicity.

Authors:  Siân R Kitcher; Nerissa K Kirkwood; Esra D Camci; Patricia Wu; Robin M Gibson; Van A Redila; Julian A Simon; Edwin W Rubel; David W Raible; Guy P Richardson; Corné J Kros
Journal:  JCI Insight       Date:  2019-08-08

8.  The Mechanotransduction Channel and Organic Cation Transporter Are Critical for Cisplatin Ototoxicity in Murine Hair Cells.

Authors:  Jinan Li; Chang Liu; Samuel Kaefer; Mariam Youssef; Bo Zhao
Journal:  Front Mol Neurosci       Date:  2022-02-10       Impact factor: 6.261

Review 9.  Role of Oxidative Stress and Antioxidants in Acquired Inner Ear Disorders.

Authors:  Megumi Kishimoto-Urata; Shinji Urata; Chisato Fujimoto; Tatsuya Yamasoba
Journal:  Antioxidants (Basel)       Date:  2022-07-27

Review 10.  Oxidative Stress and Inflammation Caused by Cisplatin Ototoxicity.

Authors:  Vickram Ramkumar; Debashree Mukherjea; Asmita Dhukhwa; Leonard P Rybak
Journal:  Antioxidants (Basel)       Date:  2021-11-29
  10 in total

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