Literature DB >> 8112040

In vitro activity of recombinant lysostaphin-antibiotic combinations toward methicillin-resistant Staphylococcus aureus.

J Polak1, P Della Latta, P Blackburn.   

Abstract

In vitro bactericidal experiments were performed with combinations of recombinant lysostaphin and various antibiotics against five strains of Staphylococcus aureus, including clinical isolates of methicillin-resistant S. aureus (MRSA). Sublethal concentrations of lysostaphin combined with beta-lactam antibiotics (including benzylpenicillin, methicillin, and cephalosporin B), bacitracin, or polymyxin B, exhibited rapid synergistic bactericidal activity against all S. aureus strains tested. Lysostaphin activity was additive when combined with either vancomycin, gentamicin, tetracycline, or erythromycin. Synergistic combinations of recombinant lysostaphin and antibiotics might be applicable to controlling cutaneous staphylococcal infections and MRSA carriage.

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Year:  1993        PMID： 8112040     DOI： 10.1016/0732-8893(93)90034-5

Source DB:  PubMed          Journal:  Diagn Microbiol Infect Dis        ISSN： 0732-8893            Impact factor:   2.803


  10 in total

1.  Bactericidal synergy of lysostaphin in combination with antimicrobial peptides.

Authors:  A P Desbois; P J Coote
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2011-02-11       Impact factor: 3.267

2.  Inhibition of Staphylococcus aureus by lysostaphin-expressing Lactobacillus plantarum WCFS1 in a modified genital tract secretion medium.

Authors:  Huanli Liu; Yuan Gao; Li-Rong Yu; Richard C Jones; Christopher A Elkins; Mark E Hart
Journal:  Appl Environ Microbiol       Date:  2011-10-07       Impact factor: 4.792

3.  Lysostaphin cream eradicates Staphylococcus aureus nasal colonization in a cotton rat model.

Authors:  John F Kokai-Kun; Scott M Walsh; Tanya Chanturiya; James J Mond
Journal:  Antimicrob Agents Chemother       Date:  2003-05       Impact factor: 5.191

4.  Deimmunized Lysostaphin Synergizes with Small-Molecule Chemotherapies and Resensitizes Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics.

Authors:  Yongliang Fang; Jack R Kirsch; Liang Li; Seth A Brooks; Spencer Heim; Cynthia Tan; Susan Eszterhas; Hao D Cheng; Hongliang Zhao; Yan Q Xiong; Karl E Griswold
Journal:  Antimicrob Agents Chemother       Date:  2021-02-17       Impact factor: 5.191

5.  An enhancer peptide for membrane-disrupting antimicrobial peptides.

Authors:  Satoshi Ueno; Kohtaro Kusaka; Yasushi Tamada; Hong Zhang; Masaomi Minaba; Yusuke Kato
Journal:  BMC Microbiol       Date:  2010-02-15       Impact factor: 3.605

6.  Synergistic Anti-Staphylococcal Activity Of Niosomal Recombinant Lysostaphin-LL-37.

Authors:  Somayeh Sadeghi; Haleh Bakhshandeh; Reza Ahangari Cohan; Afshin Peirovi; Parastoo Ehsani; Dariush Norouzian
Journal:  Int J Nanomedicine       Date:  2019-12-10

Review 7.  Lysostaphin: A Staphylococcal Bacteriolysin with Potential Clinical Applications.

Authors:  Maria do Carmo de Freire Bastos; Bruna Gonçalves Coutinho; Marcus Lívio Varella Coelho
Journal:  Pharmaceuticals (Basel)       Date:  2010-04-19

8.  In vitro activity of recombinant lysostaphin in combination with linezolid, vancomycin and oxacillin against methicillin-resistant Staphylococcus aureus.

Authors:  Nagalakshmi Narasimhaswamy; Indira Bairy; Gautham Shenoy; Laxminarayana Bairy
Journal:  Iran J Microbiol       Date:  2017-08

Review 9.  Peptidoglycan hydrolases-potential weapons against Staphylococcus aureus.

Authors:  Piotr Szweda; Marta Schielmann; Roman Kotlowski; Grzegorz Gorczyca; Magdalena Zalewska; Slawomir Milewski
Journal:  Appl Microbiol Biotechnol       Date:  2012-10-18       Impact factor: 4.813

Review 10.  Phage Lysins for Fighting Bacterial Respiratory Infections: A New Generation of Antimicrobials.

Authors:  Roberto Vázquez; Ernesto García; Pedro García
Journal:  Front Immunol       Date:  2018-10-16       Impact factor: 7.561
  10 in total

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