| Literature DB >> 8111373 |
I Danko1, J D Fritz, J S Latendresse, H Herweijer, E Schultz, J A Wolff.
Abstract
Expression of Becker-like and full-length human dystrophins was stable for at least 6 months in mdx mouse muscle following intramuscular plasmid DNA injection. Intramuscular injection of a single plasmid DNA encoding both luciferase and dystrophin resulted in stable luciferase expression for at least 2 months in mdx muscle, whereas injection of plasmid DNA encoding only luciferase did not result in stable luciferase expression. These results suggest that expression of either full-length or Becker-like dystrophins protects mdx mouse myofibers from degeneration.Entities:
Mesh：
Substances：
Year: 1993 PMID： 8111373 DOI： 10.1093/hmg/2.12.2055
Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 6.150