Literature DB >> 8110835

Isolation, structural determination and expression of a novel reg gene, human regI beta.

S Moriizumi1, T Watanabe, M Unno, K Nakagawara, Y Suzuki, H Miyashita, H Yonekura, H Okamoto.   

Abstract

We have isolated a novel human gene and cDNA encoding a member of the regI proteins, regI beta. The gene encodes a 166-amino acid protein which has 22 amino acid substitutions in comparison with the previously isolated human reg protein, regI alpha. RegI beta was expressed only in pancreas, whereas regI alpha was expressed in kidney and stomach as well as in pancreas.

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Year:  1994        PMID： 8110835     DOI： 10.1016/0167-4781(94)90035-3

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  9 in total

1.  A Brief History of Pancreatic Reg: Implications as to its Clinical Importance.

Authors:  Haiyan Wu; Qinghu Zheng; Padmanabha Rengabhashyam; Michael E Zenilman
Journal:  Einstein Q J Biol Med       Date:  2000

2.  REG Iα activates c-Jun through MAPK pathways to enhance the radiosensitivity of squamous esophageal cancer cells.

Authors:  Akiyuki Wakita; Satoru Motoyama; Yusuke Sato; Souichi Koyota; Shuetsu Usami; Kei Yoshino; Tomohiko Sasaki; Kazuhiro Imai; Hajime Saito; Yoshihiro Minamiya
Journal:  Tumour Biol       Date:  2015-02-06

3.  Polymorphisms of the reg1α gene and early onset type 2 diabetes in the korean population.

Authors:  Bo Kyung Koo; Young Min Cho; Kuchan Kimm; Jong-Young Lee; Bermseok Oh; Byung Lae Park; Hyun Sub Cheong; Hyoung Doo Shin; Kyung Soo Ko; Sang Gyu Park; Hong Kyu Lee; Kyong Soo Park
Journal:  Korean Diabetes J       Date:  2010-08-31

4.  Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein.

Authors:  T Watanabe; Y Yonemura; H Yonekura; Y Suzuki; H Miyashita; K Sugiyama; S Moriizumi; M Unno; O Tanaka; H Kondo
Journal:  Proc Natl Acad Sci U S A       Date:  1994-04-26       Impact factor: 11.205

5.  Involvement of autoimmunity to REG, a regeneration factor, in patients with primary Sjögren's syndrome.

Authors:  K Yoshimoto; T Fujimoto; A Itaya-Hironaka; T Miyaoka; S Sakuramoto-Tsuchida; A Yamauchi; M Takeda; T Kasai; K Nakagawara; A Nonomura; S Takasawa
Journal:  Clin Exp Immunol       Date:  2013-10       Impact factor: 4.330

6.  Activation of Reg gene, a gene for insulin-producing beta -cell regeneration: poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation.

Authors:  T Akiyama; S Takasawa; K Nata; S Kobayashi; M Abe; N J Shervani; T Ikeda; K Nakagawa; M Unno; S Matsuno; H Okamoto
Journal:  Proc Natl Acad Sci U S A       Date:  2001-01-02       Impact factor: 11.205

7.  Expression of REG family genes in human inflammatory bowel diseases and its regulation.

Authors:  Chikatsugu Tsuchida; Sumiyo Sakuramoto-Tsuchida; Maiko Taked; Asako Itaya-Hironaka; Akiyo Yamauchi; Masayasu Misu; Ryogo Shobatake; Tomoko Uchiyama; Mai Makino; Irma Pujol-Autonell; Marta Vives-Pi; Chiho Ohbayashi; Shin Takasawa
Journal:  Biochem Biophys Rep       Date:  2017-10-23

8.  Okamoto model for necrosis and its expansions, CD38-cyclic ADP-ribose signal system for intracellular Ca2+ mobilization and Reg (Regenerating gene protein)-Reg receptor system for cell regeneration.

Authors:  Hiroshi Okamoto; Shin Takasawa
Journal:  Proc Jpn Acad Ser B Phys Biol Sci       Date:  2021       Impact factor: 3.493

9.  Synergistic activations of REG I α and REG I β promoters by IL-6 and Glucocorticoids through JAK/STAT pathway in human pancreatic β cells.

Authors:  Akiyo Yamauchi; Asako Itaya-Hironaka; Sumiyo Sakuramoto-Tsuchida; Maiko Takeda; Kiyomi Yoshimoto; Tomoko Miyaoka; Takanori Fujimura; Hiroki Tsujinaka; Chikatsugu Tsuchida; Hiroyo Ota; Shin Takasawa
Journal:  J Diabetes Res       Date:  2015-02-12       Impact factor: 4.011
  9 in total

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