Literature DB >> 8110814

The in situ size of the dopamine transporter is a tetramer as estimated by radiation inactivation.

H E Milner1, R Béliveau, S M Jarvis.   

Abstract

Radiation inactivation analysis of the mazindol-sensitive binding of the dopamine transporter inhibitor, [3H]GBR-12935 to canine striatal membranes yielded a radiation inactivation target size of 278 +/- 16 kDa. This result, in conjunction with other findings in the literature demonstrating that the molecular mass of the dopamine transporter is approximately 70 kDa, suggests that the native form of the dopamine carrier in the neuronal membranes is a tetrameric assembly of identical 70 kDa subunits.

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Year:  1994        PMID： 8110814     DOI： 10.1016/0005-2736(94)90051-5

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  15 in total

Review 1.  The role of neurotransporters in excitotoxicity, neuronal cell death, and other neurodegenerative processes.

Authors:  K P Lesch; A Heils; P Riederer
Journal:  J Mol Med (Berl)       Date:  1996-07       Impact factor: 4.599

2.  Endogenous basic fibroblast growth factor isoforms involved in different intracellular protein complexes.

Authors:  V Patry; B Bugler; A Maret; M Potier; H Prats
Journal:  Biochem J       Date:  1997-08-15       Impact factor: 3.857

3.  Dopamine transporter oligomerization: impact of combining protomers with differential cocaine analog binding affinities.

Authors:  Juan Zhen; Tamara Antonio; Shu-Yuan Cheng; Solav Ali; Kymry T Jones; Maarten E A Reith
Journal:  J Neurochem       Date:  2015-01-26       Impact factor: 5.372

4.  Functional properties of dopamine transporter oligomers after copper linking.

Authors:  Juan Zhen; Maarten E A Reith
Journal:  J Neurochem       Date:  2017-12-21       Impact factor: 5.372

5.  The rare DAT coding variant Val559 perturbs DA neuron function, changes behavior, and alters in vivo responses to psychostimulants.

Authors:  Marc A Mergy; Raajaram Gowrishankar; Paul J Gresch; Stephanie C Gantz; John Williams; Gwynne L Davis; C Austin Wheeler; Gregg D Stanwood; Maureen K Hahn; Randy D Blakely
Journal:  Proc Natl Acad Sci U S A       Date:  2014-10-20       Impact factor: 11.205

6.  Symmetrical dimer of the human dopamine transporter revealed by cross-linking Cys-306 at the extracellular end of the sixth transmembrane segment.

Authors:  H Hastrup; A Karlin; J A Javitch
Journal:  Proc Natl Acad Sci U S A       Date:  2001-08-28       Impact factor: 11.205

Review 7.  Monoamine transporters: vulnerable and vital doorkeepers.

Authors:  Zhicheng Lin; Juan J Canales; Thröstur Björgvinsson; Morgane Thomsen; Hong Qu; Qing-Rong Liu; Gonzalo E Torres; S Barak Caine
Journal:  Prog Mol Biol Transl Sci       Date:  2011       Impact factor: 3.622

Review 8.  Regulation of the Dopamine and Vesicular Monoamine Transporters: Pharmacological Targets and Implications for Disease.

Authors:  Christopher L German; Michelle G Baladi; Lisa M McFadden; Glen R Hanson; Annette E Fleckenstein
Journal:  Pharmacol Rev       Date:  2015-10       Impact factor: 25.468

9.  Interrelation of dopamine transporter oligomerization and surface presence as studied with mutant transporter proteins and amphetamine.

Authors:  Yan Li; Shu-Yuan Cheng; Nianhang Chen; Maarten E A Reith
Journal:  J Neurochem       Date:  2010-05-18       Impact factor: 5.372

10.  Substrates dissociate dopamine transporter oligomers.

Authors:  Nianhang Chen; Maarten E A Reith
Journal:  J Neurochem       Date:  2007-12-18       Impact factor: 5.372
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