Literature DB >> 8110811

Endogenous hepoxilin A3, produced under short duration of high shear-stress, inhibits thrombin-induced aggregation in human platelets.

A Margalit1, Y Granot.   

Abstract

The effect of short duration of shear-stress (350 dyne/cm2, 20 ms) on platelet-aggregation has been assessed. This treatment inhibits thrombin-induced but not ADP- or collagen-induced aggregation. The inhibitory effect is mediated by endogenous hepoxilin A3. This conclusion is based on the following observations: (a) The shear-stress effect is abolished by lipoxygenase inhibitors. (b) Hepoxilin A3 mimics the shear-stress effect.

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Year:  1994        PMID： 8110811     DOI： 10.1016/0005-2736(94)90048-5

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  4 in total

1.  High shear stress marks: the vulnerable target with von Willebrand factor for platelet deployment -letter-.

Authors:  H Gilutz
Journal:  J Thromb Thrombolysis       Date:  2000-04       Impact factor: 2.300

2.  12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity.

Authors:  J Yeung; P L Apopa; J Vesci; M Stolla; G Rai; A Simeonov; A Jadhav; P Fernandez-Perez; D J Maloney; O Boutaud; T R Holman; M Holinstat
Journal:  Thromb Haemost       Date:  2013-06-20       Impact factor: 5.249

3.  Biotransformation of polyunsaturated fatty acids to bioactive hepoxilins and trioxilins by microbial enzymes.

Authors:  Jung-Ung An; Yong-Seok Song; Kyoung-Rok Kim; Yoon-Joo Ko; Do-Young Yoon; Deok-Kun Oh
Journal:  Nat Commun       Date:  2018-01-09       Impact factor: 14.919

4.  Growth State-Dependent Expression of Arachidonate Lipoxygenases in the Human Endothelial Cell Line EA.hy926.

Authors:  Mohammad G Sabbir; Jeffrey T Wigle; Carla G Taylor; Peter Zahradka
Journal:  Cells       Date:  2022-08-10       Impact factor: 7.666
  4 in total

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