Literature DB >> 8110810

Release of GPI-anchored membrane aminopeptidase P by enzymes and detergents has some peculiarities.

R Koelsch1, S Gottwald, J Lasch.   

Abstract

The enzyme aminopeptidase P (APP) of rat small intestine is an integral membrane protein. It is not released from the membrane by proteinases and is also resistant to bacterial inositol-specific phospholipases C (PI-PLC's). We show that this resistance is due to a hindered accessibility of the bond split by PI-PLC and not to a modified glycosylphosphatidyl inositol (GPI)-anchor.

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Year:  1994        PMID: 8110810     DOI: 10.1016/0005-2736(94)90047-7

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN: 0006-3002


  3 in total

1.  Release of GPI-anchored Zn2+-glycerophosphocholine cholinephosphodiesterase as an amphiphilic form from bovine brain membranes by bee venom phospholipase A2.

Authors:  J Y Lee; M R Kim; D E Sok
Journal:  Neurochem Res       Date:  1999-08       Impact factor: 3.996

2.  Release of the glycosylphosphatidylinositol-anchored enzyme ecto-5'-nucleotidase by phospholipase C: catalytic activation and modulation by the lipid bilayer.

Authors:  M T Lehto; F J Sharom
Journal:  Biochem J       Date:  1998-05-15       Impact factor: 3.857

3.  Cell surface antigens in renal tumour cells: detection by immunoluminescence and enzymatic analysis.

Authors:  F Laube; B Göhring; H Sann; I Willhardt
Journal:  Br J Cancer       Date:  2001-09-14       Impact factor: 7.640

  3 in total

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