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Literature DB >> 8109825

Bicyclic imidazoles as a novel class of cytokine biosynthesis inhibitors.

J C Lee¹, A M Badger, D E Griswold, D Dunnington, A Truneh, B Votta, J R White, P R Young, P E Bender.

Abstract

Entities: Chemical

Mesh：

Substances：

Year: 1993 PMID： 8109825 DOI： 10.1111/j.1749-6632.1993.tb17149.x

Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691

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13 in total

1. Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway.

Authors: M Rincón; H Enslen; J Raingeaud; M Recht; T Zapton; M S Su; L A Penix; R J Davis; R A Flavell
Journal: EMBO J Date: 1998-05-15 Impact factor: 11.598

2. Inhibition of kinases impairs neutrophil activation and killing of Staphylococcus aureus.

Authors: B Schnyder; P C Meunier; B D Car
Journal: Biochem J Date: 1998-04-15 Impact factor: 3.857

3. Role of p38 MAP kinase in LPS-induced airway inflammation in the rat.

Authors: E B Haddad; M Birrell; K McCluskie; A Ling; S E Webber; M L Foster; M G Belvisi
Journal: Br J Pharmacol Date: 2001-04 Impact factor: 8.739

4. Involvement of p38 mitogen-activated protein kinase in lipopolysaccharide-induced iNOS and COX-2 expression in J774 macrophages.

Authors: C Chen; Y H Chen; W W Lin
Journal: Immunology Date: 1999-05 Impact factor: 7.397

5. Benzydamine inhibits monocyte migration and MAPK activation induced by chemotactic agonists.

Authors: Elena Riboldi; Giada Frascaroli; Pietro Transidico; Walter Luini; Sergio Bernasconi; Francesca Mancini; Angelo Guglielmotti; Claudio Milanese; Mario Pinza; Silvano Sozzani; Alberto Mantovani
Journal: Br J Pharmacol Date: 2003-08-18 Impact factor: 8.739

Bicyclic imidazoles as a novel class of cytokine biosynthesis inhibitors.

1. Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway.

2. Inhibition of kinases impairs neutrophil activation and killing of Staphylococcus aureus.

3. Role of p38 MAP kinase in LPS-induced airway inflammation in the rat.

4. Involvement of p38 mitogen-activated protein kinase in lipopolysaccharide-induced iNOS and COX-2 expression in J774 macrophages.

5. Benzydamine inhibits monocyte migration and MAPK activation induced by chemotactic agonists.

6. p38 MAPK regulates IL-1beta induced IL-6 expression through mRNA stability in osteoblasts.

7. Role of p38 MAP kinase pathway in a toxin-induced model of hemolytic uremic syndrome.

8. Molecular basis of MAPK-activated protein kinase 2:p38 assembly.

Review 9. Role of p38 MAP Kinase Signal Transduction in Solid Tumors.

Review 10. Biological targets for therapeutic interventions in COPD: clinical potential.