Literature DB >> 8108862

Tau as a marker for Alzheimer's disease.

E M Mandelkow1, E Mandelkow.   

Abstract

Alzheimer's Disease (AD) is an age-related dementia that has received increasing attention in recent years. The disease appears to be specific for humans and, moreover, its causes are unknown. Studies of the disease are complicated by the fact that a reliable diagnosis depends on post-mortem analysis of brain tissue, and useful animal or cell models are not yet available. This article discusses the possibility of using tau (a protein associated with the neurofibrillary tangles that are an indicator of AD) as a tool for further pursuing the diagnosis and treatment of the disease.

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Year:  1993        PMID: 8108862     DOI: 10.1016/0968-0004(93)90011-b

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN: 0968-0004            Impact factor:   13.807


  20 in total

1.  Recent advances in the development of immunotherapies for tauopathies.

Authors:  Kiren Ubhi; Eliezer Masliah
Journal:  Exp Neurol       Date:  2010-10-21       Impact factor: 5.330

2.  Crowded cell-like environment accelerates the nucleation step of amyloidogenic protein misfolding.

Authors:  Zheng Zhou; Jun-Bao Fan; Hai-Li Zhu; Frank Shewmaker; Xu Yan; Xi Chen; Jie Chen; Geng-Fu Xiao; Lin Guo; Yi Liang
Journal:  J Biol Chem       Date:  2009-09-10       Impact factor: 5.157

3.  Functional interactions between the proline-rich and repeat regions of tau enhance microtubule binding and assembly.

Authors:  B L Goode; P E Denis; D Panda; M J Radeke; H P Miller; L Wilson; S C Feinstein
Journal:  Mol Biol Cell       Date:  1997-02       Impact factor: 4.138

4.  Phosphorylated tau can promote tubulin assembly.

Authors:  H C Tseng; Q Lu; E Henderson; D J Graves
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-17       Impact factor: 11.205

Review 5.  Immunotherapy for neurodegenerative diseases: focus on α-synucleinopathies.

Authors:  Elvira Valera; Eliezer Masliah
Journal:  Pharmacol Ther       Date:  2013-02-04       Impact factor: 12.310

Review 6.  Alzheimer's disease: fundamental and therapeutic aspects.

Authors:  M Schorderet
Journal:  Experientia       Date:  1995-02-15

7.  Stress-induced tau phosphorylation in mouse strains with different brain Erk 1 + 2 immunoreactivity.

Authors:  A Y Korneyev
Journal:  Neurochem Res       Date:  1998-12       Impact factor: 3.996

Review 8.  Immunotherapeutic Approaches Targeting Amyloid-β, α-Synuclein, and Tau for the Treatment of Neurodegenerative Disorders.

Authors:  Elvira Valera; Brian Spencer; Eliezer Masliah
Journal:  Neurotherapeutics       Date:  2016-01       Impact factor: 7.620

9.  A human ubiquitin conjugating enzyme, L-UBC, maps in the Alzheimer's disease locus on chromosome 14q24.3.

Authors:  P A Robinson; J P Leek; J Thompson; I M Carr; A Bailey; T P Moynihan; P L Coletta; N J Lench; A F Markham
Journal:  Mamm Genome       Date:  1995-10       Impact factor: 2.957

10.  In situ determination of a PKA phosphorylation site in the C-terminal region of filamin.

Authors:  David Jay; Elizabeth J García; María de la Luz Ibarra
Journal:  Mol Cell Biochem       Date:  2004-05       Impact factor: 3.396

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