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Literature DB >> 8107774

A brain serine/threonine protein kinase activated by Cdc42 and Rac1.

E Manser¹, T Leung, H Salihuddin, Z S Zhao, L Lim.

Abstract

A new brain serine/threonine protein kinase may be a target for the p21ras-related proteins Cdc42 and Rac1. The kinase sequence is related to that of the yeast protein STE20, implicated in pheromone-response pathways. The kinase complexes specifically with activated (GTP-bound) p21, inhibiting p21 GTPase activity and leading to kinase autophosphorylation and activation. Autophosphorylated kinase has a decreased affinity for Cdc42/Rac, freeing the p21 for further stimulatory activities or downregulation by GTPase-activating proteins. This bimolecular interaction provides a model for studying p21 regulation of mammalian phosphorylation signalling pathways.

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Year: 1994 PMID： 8107774 DOI： 10.1038/367040a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

476 in total

1. Cytoskeletal reorganization induced by engagement of the NG2 proteoglycan leads to cell spreading and migration.

Authors: X Fang; M A Burg; D Barritt; K Dahlin-Huppe; A Nishiyama; W B Stallcup
Journal: Mol Biol Cell Date: 1999-10 Impact factor: 4.138

2. S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3.

Authors: A Chiloeches; C S Mason; R Marais
Journal: Mol Cell Biol Date: 2001-04 Impact factor: 4.272

3. Functional characterization of the interaction of Ste50p with Ste11p MAPKKK in Saccharomyces cerevisiae.

Authors: C Wu; E Leberer; D Y Thomas; M Whiteway
Journal: Mol Biol Cell Date: 1999-07 Impact factor: 4.138

4. MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts.

Authors: P D Burbelo; D M Snow; W Bahou; S Spiegel
Journal: Proc Natl Acad Sci U S A Date: 1999-08-03 Impact factor: 11.205

Review 5. Rho GTPases and their effector proteins.

Authors: A L Bishop; A Hall
Journal: Biochem J Date: 2000-06-01 Impact factor: 3.857

6. Arabidopsis RopGAPs are a novel family of rho GTPase-activating proteins that require the Cdc42/Rac-interactive binding motif for rop-specific GTPase stimulation.

Authors: G Wu; H Li; Z Yang
Journal: Plant Physiol Date: 2000-12 Impact factor: 8.340

A brain serine/threonine protein kinase activated by Cdc42 and Rac1.

1. Cytoskeletal reorganization induced by engagement of the NG2 proteoglycan leads to cell spreading and migration.

2. S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3.

3. Functional characterization of the interaction of Ste50p with Ste11p MAPKKK in Saccharomyces cerevisiae.

4. MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts.

Review 5. Rho GTPases and their effector proteins.

6. Arabidopsis RopGAPs are a novel family of rho GTPase-activating proteins that require the Cdc42/Rac-interactive binding motif for rop-specific GTPase stimulation.

7. Identification of the endogenous smooth muscle myosin phosphatase-associated kinase.

8. The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner.

9. In vivo modifications of small GTPase Rac and Cdc42 by Bordetella dermonecrotic toxin.

10. Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1.