Literature DB >> 8105867

Genistein modulates the decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumour cells.

C H Versantvoort1, G J Schuurhuis, H M Pinedo, C A Eekman, C M Kuiper, J Lankelma, H J Broxterman.   

Abstract

In tumour cells the pharmacological basis for multidrug resistance (MDR) often appears to be a reduced cellular cytostatic drug accumulation caused by the drug efflux protein, P-glycoprotein (Pgp MDR), or by other drug transporters (non-Pgp MDR). Here we report the reversal of the decreased daunorubicin (DNR) accumulation in five non-Pgp MDR cell lines (GLC4/ADR, SW-1573/2R120, HT1080/DR4, MCF7/Mitox and HL60/ADR) by genistein. Genistein inhibited the enhanced DNR efflux in the GLC4/ADR cells. In these cells the decreased VP-16 accumulation was also reversed by genistein. Three other (iso)flavonoids biochanin A, apigenin and quercetin also increased the DNR accumulation in the GLC4/ADR cells. In contrast to the effects on non-Pgp MDR cells, 200 microM genistein did not increase the reduced DNR accumulation in three Pgp MDR cell lines (SW-1573/2R160, MCF7/DOX40 and KB8-5) or in the parental cell lines. In conclusion the use of genistein provides a means to probe non-Pgp related drug accumulation defects.

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Year:  1993        PMID： 8105867      PMCID： PMC1968712          DOI： 10.1038/bjc.1993.458

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  41 in total

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Authors:  G Yu; S Ahmad; A Aquino; C R Fairchild; J B Trepel; S Ohno; K Suzuki; T Tsuruo; K H Cowan; R I Glazer
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Review 3.  Membrane transport of anthracyclines.

Authors:  T Skovsgaard; N I Nissen
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4.  Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II.

Authors:  J Markovits; C Linassier; P Fossé; J Couprie; J Pierre; A Jacquemin-Sablon; J M Saucier; J B Le Pecq; A K Larsen
Journal:  Cancer Res       Date:  1989-09-15       Impact factor: 12.701

5.  Genistein, a specific inhibitor of tyrosine-specific protein kinases.

Authors:  T Akiyama; J Ishida; S Nakagawa; H Ogawara; S Watanabe; N Itoh; M Shibuya; Y Fukami
Journal:  J Biol Chem       Date:  1987-04-25       Impact factor: 5.157

6.  Phorbol esters induce multidrug resistance in human breast cancer cells.

Authors:  R L Fine; J Patel; B A Chabner
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7.  Pharmacological and biological evidence for differing mechanisms of doxorubicin resistance in two human tumor cell lines.

Authors:  M L Slovak; G A Hoeltge; W S Dalton; J M Trent
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8.  Increase of daunorubicin and vincristine accumulation in multidrug resistant human ovarian carcinoma cells by a monoclonal antibody reacting with P-glycoprotein.

Authors:  H J Broxterman; C M Kuiper; G J Schuurhuis; T Tsuruo; H M Pinedo; J Lankelma
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10.  Effect of calcium antagonists on the chemosensitivity of two multidrug-resistant human tumour cell lines which do not overexpress P-glycoprotein.

Authors:  S P Cole; H F Downes; M L Slovak
Journal:  Br J Cancer       Date:  1989-01       Impact factor: 7.640
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  16 in total

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2.  The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.

Authors:  G J Zaman; M J Flens; M R van Leusden; M de Haas; H S Mülder; J Lankelma; H M Pinedo; R J Scheper; F Baas; H J Broxterman
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3.  In vitro antileukaemic activity of extracts from Daphne gnidium leaves against sensitive and multidrug resistant K562/R7 cells.

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Review 4.  Development of multidrug-resistance convertors: sense or nonsense?

Authors:  L van Zuylen; K Nooter; A Sparreboom; J Verweij
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5.  An in silico approach for screening flavonoids as P-glycoprotein inhibitors based on a Bayesian-regularized neural network.

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6.  A new method to measure intestinal activity of P-glycoprotein in avian and mammalian species.

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7.  Glyceollin transport, metabolism, and effects on p-glycoprotein function in Caco-2 cells.

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Review 8.  Phytoestrogens: epidemiology and a possible role in cancer protection.

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9.  Functional detection of MDR1/P170 and MRP/P190-mediated multidrug resistance in tumour cells by flow cytometry.

Authors:  N Feller; C M Kuiper; J Lankelma; J K Ruhdal; R J Scheper; H M Pinedo; H J Broxterman
Journal:  Br J Cancer       Date:  1995-09       Impact factor: 7.640

10.  Regulation by glutathione of drug transport in multidrug-resistant human lung tumour cell lines overexpressing multidrug resistance-associated protein.

Authors:  C H Versantvoort; H J Broxterman; T Bagrij; R J Scheper; P R Twentyman
Journal:  Br J Cancer       Date:  1995-07       Impact factor: 7.640
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