Literature DB >> 8104886

Adhesion of CD16+ K cells to antibody-coated targets is mediated by CD2 and CD18 receptors.

J C Voltarelli1, G Gjerset, C Anasetti.   

Abstract

In order to investigate the function of CD2 and CD18 receptors in antibody-dependent cellular cytotoxicity (ADCC), Fab' fragments of the monoclonal antibodies 9.6 (anti-CD2) and 60.3 (anti-CD18) were preincubated with the human natural killer (NK) clone EB4.19 and tested for conjugate formation and cytotoxic function against the human B-cell line KMS and the mouse thymoma line SL-2. We concluded that: (1) the FcR CD16 does not participate in conjugate formation; (2) adhesion between target and effector cells mediated by CD2 and CD18 is a prerequisite for subsequent activation of the lytic programme through the CD16 receptor.

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Year:  1993        PMID： 8104886      PMCID： PMC1421975     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  15 in total

Review 1.  Target structures involved in natural killing (NK): characteristics, distribution, and candidate molecules.

Authors:  W J Storkus; J R Dawson
Journal:  Crit Rev Immunol       Date:  1991       Impact factor: 2.214

2.  Regulatory function of cell surface molecules CD2-, LFA- and beta 2-microglobulin in natural killer cell activity.

Authors:  G G Petrányi; E Pócsik; B Kotlán; G Görög; M Benczur
Journal:  Mol Immunol       Date:  1986-11       Impact factor: 4.407

3.  Induction and blocking of cytolysis in CD2+, CD3- NK and CD2+, CD3+ cytotoxic T lymphocytes via CD2 50 KD sheep erythrocyte receptor.

Authors:  R L Bolhuis; R C Roozemond; R J van de Griend
Journal:  J Immunol       Date:  1986-06-01       Impact factor: 5.422

Review 4.  The human NK cell--a short over-view and an hypothesis on NK recognition.

Authors:  M Jondal
Journal:  Clin Exp Immunol       Date:  1987-11       Impact factor: 4.330

5.  Inhibition of natural killer cell cytotoxicity by a monoclonal antibody directed against adhesion-mediating protein gp 90 (CD18).

Authors:  I Axberg; U Ramstedt; M Patarroyo; P Beatty; H Wigzell
Journal:  Scand J Immunol       Date:  1987-11       Impact factor: 3.487

6.  The Fc receptor for IgG on human natural killer cells: phenotypic, functional, and comparative studies with monoclonal antibodies.

Authors:  B Perussia; G Trinchieri; A Jackson; N L Warner; J Faust; H Rumpold; D Kraft; L L Lanier
Journal:  J Immunol       Date:  1984-07       Impact factor: 5.422

7.  Evidence for T cell nature and heterogeneity within natural killer (NK) and antibody-dependent cellular cytotoxicity (ADCC) effectors: a comparison with cytolytic T lymphocytes (CTL).

Authors:  L D Fast; J A Hansen; W Newman
Journal:  J Immunol       Date:  1981-08       Impact factor: 5.422

8.  Both Fc receptors and lymphocyte-function-associated antigen 1 on human T gamma lymphocytes are required for antibody-dependent cellular cytotoxicity (killer cell activity).

Authors:  F Miedema; P A Tetteroo; W G Hesselink; G Werner; H Spits; C J Melief
Journal:  Eur J Immunol       Date:  1984-06       Impact factor: 5.532

9.  The lymphocyte function-associated antigen (LFA)-1 and CD2/LFA-3 pathways of antigen-independent human T cell adhesion.

Authors:  S Shaw; G E Luce
Journal:  J Immunol       Date:  1987-08-15       Impact factor: 5.422

10.  Human large granular lymphocytes express high affinity receptors for murine monoclonal antibodies of the IgG3 subclass.

Authors:  C Anasetti; P J Martin; Y Morishita; C C Badger; I D Bernstein; J A Hansen
Journal:  J Immunol       Date:  1987-05-01       Impact factor: 5.422
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  2 in total

1.  NK-cell activation and antibody-dependent cellular cytotoxicity induced by rituximab-coated target cells is inhibited by the C3b component of complement.

Authors:  Siao-Yi Wang; Emilian Racila; Ronald P Taylor; George J Weiner
Journal:  Blood       Date:  2007-11-16       Impact factor: 22.113

2.  Identification of the predominant human NK cell effector subset mediating ADCC against HIV-infected targets coated with BNAbs or plasma from PLWH.

Authors:  Costin Tomescu; Kyle Kroll; Krystal Colon; Emmanouil Papasavvas; Ian Frank; Pablo Tebas; Karam Mounzer; Roger Keith Reeves; Luis J Montaner
Journal:  Eur J Immunol       Date:  2021-06-19       Impact factor: 6.688
  2 in total

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