Literature DB >> 8104876

New polymorphism for the human serotonin 1D receptor variant (5-HT1D beta) not linked to schizophrenia in five Canadian pedigrees.

D G Sidenberg1, A S Bassett, L Demchyshyn, H B Niznik, F Macciardi, A B Kamble, W G Honer, J L Kennedy.   

Abstract

A new HincII polymorphism for the human serotonin 1D receptor variant (5-HT1D beta) is reported. In light of evidence indicating possible dysfunction of the 5-HT neurotransmitter system in schizophrenia, this new 5-HT receptor polymorphism was tested for linkage to schizophrenia in 5 Canadian pedigrees. Although 1 of the 5 pedigrees tested had a slightly positive lod score, there was no evidence overall for linkage to schizophrenia under dominant, recessive, or two locus models.

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Year:  1993        PMID： 8104876     DOI： 10.1159/000154150

Source DB:  PubMed          Journal:  Hum Hered        ISSN： 0001-5652            Impact factor:   0.444


  3 in total

1.  Genetic linkage evaluation of twenty-four loci in an eastern Canadian family segregating Darier's disease (keratosis follicularis).

Authors:  D G Sidenberg; D Berg; A S Bassett; N King; A Petronis; A B Kamble; J L Kennedy
Journal:  J Am Acad Dermatol       Date:  1994-07       Impact factor: 11.527

Review 2.  Molecular genetics of schizophrenia: past, present and future.

Authors:  Suman Prasad; Prachi Semwal; Smita Deshpande; Triptish Bhatia; V L Nimgaonkar; B K Thelma
Journal:  J Biosci       Date:  2002-02       Impact factor: 1.826

3.  No evidence for linkage of the CHRNA7 gene region in Canadian schizophrenia families.

Authors:  M Neves-Pereira; A S Bassett; W G Honer; D Lang; N A King; J L Kennedy
Journal:  Am J Med Genet       Date:  1998-09-07
  3 in total

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