Literature DB >> 8104155

Immunohistochemical analysis of gastrointestinal carcinoids.

H Hayashi1, M Nakagawa, S Kitagawa, T Yamada, K Ishida, H Kurumaya.   

Abstract

Clinicopathological and immunohistochemical analyses were performed on ten samples of gastrointestinal carcinoids resected in Ishikawa Prefectural Central Hospital. All samples showed positive reaction to chromogranin A. Serotonin was detected in 8 samples, somatostatin in 4 samples, gastrin in 2 samples. Glucagon/Glicentin in 1 sample, and PYY production in 2 samples. CEA production was detected in 8 samples, and microvascular invasion was observed in 6 of these 8 patients. The PCNA/cyclin labeling index (L.I.) of the cases with metastases was significantly higher than those without metastases. In conclusion, the expression of CEA and the PCNA/cyclin L.I. may be useful markers of the malignant potential of carcinoid tumors.

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Year:  1993        PMID： 8104155     DOI： 10.1007/bf02776945

Source DB:  PubMed          Journal:  Gastroenterol Jpn        ISSN： 0435-1339


  13 in total

1.  Pathologic analysis of carcinoids. Histologic reevaluation of 62 cases.

Authors:  J Soga; K Tazawa
Journal:  Cancer       Date:  1971-10       Impact factor: 6.860

2.  Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.

Authors:  S M Hsu; L Raine; H Fanger
Journal:  J Histochem Cytochem       Date:  1981-04       Impact factor: 2.479

3.  Analysis of proliferative grade using anti-PCNA/cyclin monoclonal antibodies in fixed, embedded tissues. Comparison with flow cytometric analysis.

Authors:  R L Garcia; M D Coltrera; A M Gown
Journal:  Am J Pathol       Date:  1989-04       Impact factor: 4.307

4.  Biological and clinicopathological significance of endocrine differentiation of gastric adenocarcinoma evaluated by double immunohistochemical labeling for chromogranin A and bromodeoxyuridine.

Authors:  H Hayashi; A Ooi; I Nakanishi
Journal:  Jpn J Clin Oncol       Date:  1990-12       Impact factor: 3.019

5.  Phenotypic heterogeneity studied by immunohistochemistry and aneuploidy in non-small cell lung cancers.

Authors:  J L Pujol; J Simony; J C Laurent; G Richer; H Mary; J Bousquet; P Godard; F B Michel
Journal:  Cancer Res       Date:  1989-05-15       Impact factor: 12.701

6.  Peptide YY (PYY) immunoreactivity is co-stored with glucagon-related immunoreactants in endocrine cells of the gut and pancreas.

Authors:  A Ali-Rachedi; I M Varndell; T E Adrian; D A Gapp; S Van Noorden; S R Bloom; J M Polak
Journal:  Histochemistry       Date:  1984

7.  Immunohistochemical detection of proliferating cell nuclear antigen in solid human malignancies.

Authors:  B A Robbins; D de la Vega; K Ogata; E M Tan; R M Nakamura
Journal:  Arch Pathol Lab Med       Date:  1987-09       Impact factor: 5.534

8.  Endocrine cells in human intestine: an immunocytochemical study.

Authors:  K Sjölund; G Sandén; R Håkanson; F Sundler
Journal:  Gastroenterology       Date:  1983-11       Impact factor: 22.682

9.  Flow cytometric analysis of DNA ploidy level in paraffin-embedded tissue of non-small-cell lung cancer.

Authors:  G P ten Velde; B Schutte; A Vermeulen; A Volovics; M M Reynders; G H Blijham
Journal:  Eur J Cancer Clin Oncol       Date:  1988-03

10.  Peptide YY immunoreactive cells in gastrointestinal carcinoids: immunohistochemical and ultrastructural studies of 60 tumors.

Authors:  M Iwafuchi; H Watanabe; N Ishihara; T Shimoda; A Iwashita; S Ito
Journal:  Hum Pathol       Date:  1986-03       Impact factor: 3.466
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  1 in total

1.  Gastric neuroendocrine carcinoma associated with chronic atrophic gastritis type A.

Authors:  Y Kaizaki; T Fujii; T Kawai; K Saito; K Kurihara; M Fukayama
Journal:  J Gastroenterol       Date:  1997-10       Impact factor: 7.527
  1 in total

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