Literature DB >> 8103582

Pharmacological effects of ibudilast on cerebral circulation: a PET study.

H Fukuyama1, J Kimura, S Yamaguchi, H Yamauchi, M Ogawa, T Doi, Y Yonekura, J Konishi.   

Abstract

To evaluate the pharmacological effects of ibudilast on cerebral circulation, we examined 5 ischaemic stroke patients, using positron emission tomography, and we measured cerebral blood flow (CBF). Ibudilast loading per os led to a remarkable increase in CBF after 30 min. This CBF elevation was observed in the lesion side as well as in the nonlesion hemisphere. Therefore, we can confirm that ibudilast ameliorates the chronic low perfusion state of CBF in the ischaemic stroke patient.

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Year:  1993        PMID： 8103582     DOI： 10.1080/01616412.1993.11740130

Source DB:  PubMed          Journal:  Neurol Res        ISSN： 0161-6412            Impact factor:   2.448


  5 in total

1.  Ibudilast attenuates astrocyte apoptosis via cyclic GMP signalling pathway in an in vitro reperfusion model.

Authors:  K Takuma; E Lee; R Enomoto; K Mori; A Baba; T Matsuda
Journal:  Br J Pharmacol       Date:  2001-07       Impact factor: 8.739

2.  Evidence of misery perfusion and risk for recurrent stroke in major cerebral arterial occlusive diseases from PET.

Authors:  H Yamauchi; H Fukuyama; Y Nagahama; H Nabatame; K Nakamura; Y Yamamoto; Y Yonekura; J Konishi; J Kimura
Journal:  J Neurol Neurosurg Psychiatry       Date:  1996-07       Impact factor: 10.154

3.  The glial modulatory drug AV411 attenuates mechanical allodynia in rat models of neuropathic pain.

Authors:  Annemarie Ledeboer; Tongyao Liu; Jennifer A Shumilla; John H Mahoney; Sharmila Vijay; Matthew I Gross; Joseph A Vargas; Lance Sultzbaugh; Mark D Claypool; Laura M Sanftner; Linda R Watkins; Kirk W Johnson
Journal:  Neuron Glia Biol       Date:  2006-11

4.  Developing Novel Therapies for Degenerative Cervical Myelopathy [AO Spine RECODE-DCM Research Priority Number 7]: Opportunities From Restorative Neurobiology.

Authors:  Aref-Ali Gharooni; Brian K Kwon; Michael G Fehlings; Timothy F Boerger; Ricardo Rodrigues-Pinto; Paul Aarne Koljonen; Shekar N Kurpad; James S Harrop; Bizhan Aarabi; Vafa Rahimi-Movaghar; Jefferson R Wilson; Benjamin M Davies; Mark R N Kotter; James D Guest
Journal:  Global Spine J       Date:  2022-02

5.  A double-blind, randomized, placebo-controlled pilot trial to determine the efficacy and safety of ibudilast, a potential glial attenuator, in chronic migraine.

Authors:  Yuen H Kwok; James E Swift; Parisa Gazerani; Paul Rolan
Journal:  J Pain Res       Date:  2016-10-31       Impact factor: 3.133
  5 in total

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